Biomedical subjects

K Nudleman

Publications and source records attributed to K Nudleman.

4 recordsLinked to original sources

PubMed1985

Cognitive evoked potentials (P300) in early Huntington's disease.

The P3 component of both auditory-event- and visual-event-related potentials of 13 patients with Huntington's disease was studied and compared with the P3 component of normal patients. The latencies of the patients' P3 components were compared with the latency-age regression lines generated by the normal population in both modalities. A P3 latency was considered abnormal if it fell above the 2-SE limit for the latency-age regression line. The incidence of normal or abnormal P3 latencies in the two modalities was compared with the results of computed tomography, electroencephalography, and neuropsychological testing. Nine patients had abnormal P3 latencies and ten patients had abnormal visual P3 latencies, with seven having abnormal latencies on both tests and 12 having abnormal latencies on one of the two tests. An abnormal P3 latency in one modality did not imply an abnormal P3 latency in the other. An abnormality of the P3 latency did not correlate with an abnormality in results from computed tomography, electroencephalography, or neuropsychological testing.

Adult↗

PubMed1979

Cord to cortex conduction in multiple sclerosis.

We studied 30 controls and 28 patients with multiple sclerosis (MS). M-waves, F-waves, and somatosensory responses evoked by median and peroneal nerve stimulation were used to estimate conduction times from the lumbar cord to the cortex; the cervical cord to the cortex; through the spinal cord; and in proximal segments of peripheral nerve. The central conduction times were significantly prolonged in the MS patients, giving an overall 79 percent incidence of abnormalities. Several patients who were asymptomatic in the tested arm (36 percent) or leg (16 percent) showed electrophysiologic abnormalities. By comparing conduction time from the lumbar cord to the cortex with the conduction time from the cervical cord to the cortex, the site of the lesion could be deduced, but not proven. The diagnostic yield from measuring the latencies of the somatosensory responses was 68 percent. We concluded that measuring central conduction times indirectly by use of M- and F-waves adds little to simple measurement of somatosensory responses.

Adult↗

PubMed1979

Short-latency somatosensory responses in multiple sclerosis.

Cervical and cortical somatosensory evoked potentials were measured in 80 patients with suspected or established multiple sclerosis (MS). The cervical response was a more sensitive diagnostic indicator than the cortical response, and was abnormal in 86.7 percent of patients with definite MS and in 40.9 percent of MS suspects. The complementary value of measuring both responses was greatest (89.3 percent) in early probable or latent MS. Comparing the responses obtained from stimulation of the left and right extremities increased the overall diagnostic yield by 25 percent. Abnormal responses were frequently obtained from clinically normal limbs.

Adolescent↗

PubMed1978

F-wave and cervical somatosensory response conduction from the seventh cervical spinous process to cortex in multiple sclerosis.

Transit (conduction) times from the wrist to the seventh cervical spinous process (C7) were measured by using the F-wave response (TA) and the cervical somatosensory response (SEPC). The mean values obtained in 25 controls were 10.1 +/- 0.9 s-3 and 10.9 +/- 1.0 s-1 respectively. The 0.8 +/- 1.0 s-3 difference between the two methods represents central delay of SEPC, possibly at the level of the dorsal root ganglion. The mean onset latency of the cortical somatosensory response (SEPA) evoked by median nerve stimulation in the same subjects was 15.5 +/- 1.0 s-3. Transit time from C7 to the cortex (TB) given by either SEPA - TA or SEPA - SEPC - 0.8, where 0.8 is the necessary corrective factor for central delay of SEPC, WAS 5.3 +/- 1.0 S-3. These techniques were applied to 10 patients suspected of having multiple sclerosis, but without clinical evidence of involvement above C7. Six of the 10 cases showed prolongation of TB. In 4 of these, this could only be calculated by the F-wave method since SEPC was absent. It is concluded that transit times derived from either the F-wave or SEPC are equally valid and interchangeable. The absence of one response allows for its replacement by the other.

Action Potentials↗