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Biomedical subjects

K Numata

Publications and source records attributed to K Numata.

At least 127 records · Page 7Linked to original sources
PubMed1987

Effect of high-frequency ventilation on extravascular lung water volume in dogs.

We studied the effect of high-frequency ventilation (HFV) (3 Hz for 2 h) on extravascular lung water in normal dogs and dogs with pulmonary edema. We used an endobronchial dividing tube to ventilate one lung with HFV and to keep the contralateral lung of the same dog static with an identical airway pressure, allowing each animal to serve as its own control. Results showed no change in the extravascular lung water with HFV compared with the static lungs in normal, mild pulmonary edema, and severe pulmonary edema groups. We conclude that HFV has no appreciable effect on lung fluid balance; the lymphatic system retains its ability to increase flow even with experimentally produced pulmonary edema.

Animals↗
PubMed1986

Isolation of an aminoglycoside hypersensitive mutant and its application in screening.

An aminoglycoside hypersensitive mutant, Kp-126, was isolated from the aminoglycoside-resistant strain, Kp-8, of Klebsiella pneumoniae through selection using sorbistin, a non-aminocyclitol-aminoglycoside antibiotic. The mutant Kp-126 was approximately 100-fold more sensitive to sorbistin than the parent strain Kp-8. The mutant also showed hypersensitivity to various aminocyclitol-aminoglycoside antibiotics. K. pneumoniae Kp-126 was used in screening and a new aminoglycoside antibiotic, 3,3'-neotrehalosadiamine (BMY-28251), was discovered in the fermentation broths of soil isolate strain of Bacillus pumilus.

Aminoglycosides↗
PubMed1985

PaO2 change during progressive pulmonary edema in dogs.

We observed the changes of PaO2, pulmonary shunt (Qsp/Qt), effective compliance, and direct lung impedance after induction of hydrostatic pulmonary edema in five mongrel dogs. Edema was induced by elevating left atrial pressure in a stepwise manner while the dogs were ventilated with continuous positive pressure. Corresponding morphologic changes in the lung were examined by light and electron microscopy. PaO2 changed little or slightly until mean left atrial pressure reached 40 to 60 mm Hg. PaO2 then rapidly decreased from 411 +/- 61 to 89 +/- 19 torr, accompanied by an increase in Qsp/Qt from 33 +/- 6% to 57 +/- 14%. Effective compliance decreased gradually and direct lung impedance decreased rather steeply at first and then gradually. Lung specimens taken before the abrupt fall of PaO2 revealed froth on the cut surface, indicating that alveolar pulmonary edema preceded the PaO2 decrease. Electron microscopy showed widening and splitting of the thin portion of the alveolar-capillary interstitium when PaO2 fell abruptly. This widening of the thin portion may have been one of the causes of an abrupt PaO2 fall in the dog subjected to volume overload and increased afterload.

Animals↗
PubMed1984

Empedopeptin (BMY-28117), a new depsipeptide antibiotic. II. Structure determination.

Structure of a new antibiotic, empedopeptin, has been determined. It is a cyclic depsipeptide composed of two mol of D-serine and one mol each of beta-hydroxytetradecanoic acid, L-arginine, D- and L-proline, L-3-hydroxyproline and D- and L-beta-hydroxyaspartic acid. The sequence of these moieties was established by partial hydrolysis and mass spectral analysis of the antibiotic.

Amino Acid Sequence↗