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Biomedical subjects

K O Goh

Publications and source records attributed to K O Goh.

At least 37 records · Page 2Linked to original sources
PubMed1975

Mitogenic stimulation of lymphocytes in cancer patients.

Peripheral blood lymphocytes obtained from 16 controls, 16 untreated cancer patients and 15 cancer patients treated with irradiation were cultured with phytohemagglutinin (PHA) and pokeweed mitogen (PWM). The cultures were terminated on 3 and 7 days of incubation, and mitotic rates were obtained. The mitotic rates of untreated cancer patients for both mitogens did not differ significantly from those of controls. However, the mitotic rate obtained for 3-day PHA culture of the radiation-treated cancer patients was significantly different from controls, whereas the 7-day mitotic rate stimulated by PWM was significantly lower than the untreated cancer patients and controls.

Adult↗
PubMedDate not supplied

Leukemia in radiation-treated patients: cytogenetic studies in eight cases.

Abnormal chromosomes have been found in various clinical settings and in cancer patients. Eight patients developed leukemia several years after the diagnosis and treatment of a primary malignant disease. All the patients were being treated with irradiation, and five of them also received chemotherapy, notably, alkylating agents. The type of leukemias and the interval between irradiation and leukemia parallel very well with those reported from the atomic bomb casualties. Chromosomal abnormalities were seen in all the patients. These abnormalities have been reported in irradiated normal persons without developed leukemias. These findings suggest that the development of clinical cancer or leukemia may depend, not only on the presence of abnormal cells, but also on other factors. Perhaps the environment that allowed the original cancer to develop in our patients is capable of allowing the radiation-induced abnormal cells to be expressed as clinical leukemia.

Acute Disease↗
PubMedDate not supplied

Chromosomes and B and T cells in mycosis fungoides.

Because mycosis fungoides (MF) and Sézary syndrome (SS) share several features, some investigators have considered them to be different stages of the same disease. Others view them as separate entities. Cytogenetic studies in four typical MF patients showed that the chromosomal abnormalities were different from those reported in SS patients, and the abnormalities were found with almost equal frequency in both B and T cells. In addition, we found the frequencies of the T cells in six of the eight peripheral blood determinations in three patients were within normal range. These observations support the possibility that MF and SS are two separate disease entities.

Aged↗
PubMedDate not supplied

Abnormal chromosomes in histocytic lymphoma.

Five of six diffuse histocytic lymphoma patients had chromosomal abnormalities. Four had abnormal clones; three, a large acrocentric chromosome (LAC); and one, an abnormal large submetacentric chromosome (LSC). The LAC was a 14q+ and the LSC, a 4q+. Although no cytogenetic abnormality was found in a normal lymph node of a patient whose diseased lymph node had an LAC, abnormal chromosomes were seen in three patients with normal morphological bone marrow and in two peripheral blood specimens with a normal differential count. Since staging is important in aiding the clinician to select the type of treatment in this disease, it is recommended that cytogenetic studies in all biopsied tissues should be done as part of an overall diagnostic procedure in patients suspected of this disease.

Aged↗
PubMedDate not supplied

Sister chromatid exchange in normal adults long after thymus irradiation.

Chromosomal breaks are seen in the peripheral blood lymphocytes of irradiated patients long after the original exposure. This is confirmed in our present investigation. We found 141 (20%) chromosomal breaks in 707 metaphases from 18 thymus-irradiated patients and only 26 (6.3%) in 410 metaphases from six of their normal siblings. Sister chromatid exchange (SCE) has been used to test the mutagen-carcinogen agents. However, radiation, a well-known mutagen-carcinogen agent, has no effect upon SCE. This suggests that the SCE and chromosomal breakage mechanisms may be quite different; study of them may help us to understand chromosomal breakage and healing.

Adult↗