Biomedical subjects

K O Möller

Publications and source records attributed to K O Möller.

21 records · Page 2Linked to original sources

PubMed1988

[Laser-induced shockwave lithotripsy--in vitro trial and animal experiment studies].

Laser induced shock wave lithotripsy is a new procedure to destroy gallstones. Stones of up to 500 mg are destroyed within 5 min. Severe reactions of the soft tissue cannot be observed in animal studies. No perforations, stenoses or thermic lesions after wound healing were observed. The development of an optomechanical transducer replacing the optical lens system at the end of the transmission guide allows its handling in flexible endoscopes. Clinical use is therefore possible from the technical aspect.

Animals↗

PubMedDate not supplied

[Experimental results of cartilage abrasion with an excimer laser. Histologic and electron microscopy studies].

Experiments carried out with cadaver cartilage from the tibiaplateau were performed using an excimer-laser to demonstrate its use for cartilage removal. Laser applications resulted in a cartilage ablation depending on energy density and the number of applied pulses. Observations made using scanning electron-microscopy showed the influence of the pulse rate on the surface structure. Transmission-electron-microscopical investigation showed the existence of a superficially altered layer with a depth of approx. 6 microns. On the basis of the results obtained, the conclusion can be reached that application of excimer-lasers for cartilage removal in a view of future endoscopic surgery could become a valuable alternative to the existing methods in the therapy of osteoarthritis.

Cartilage, Articular↗

PubMedDate not supplied

Experimental salvage of the spleen. A combined technique of cryosurgery and tissue sealant.

The goal of this investigation has been to improve the safety of intra- and post-operative haemostasis in splenic lesions by a combined technique of tissue freezing followed by the application of collagen fleece and fibrin glue in an animal study. The progression of healing was observed after different periods of time. Grade II lesions were set on the spleens of 15 pigs. The wounds were frozen for 1 m at -60 degrees C with a cryosurgical probe and afterwards sealed with fibrin glue and collagen fleece. In every case, complete haemostasis was achieved intraoperatively. The spleens of 3 animals each were examined microscopically after 2 days, 1, 2, 5 and 6 weeks, respectively. A visceroperitoneal adhesion was observed in only 1 spleen and u-shaped viscerovisceral adhesions in 5 spleens. Superficial coagulation necroses were observed only in specimens removed after 2 days and 1 week, respectively. Complete and safe haemostasis followed by acceptable subsequent healing was achieved using this combined technique.

Animals↗