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Biomedical subjects

K O Schmid

Publications and source records attributed to K O Schmid.

At least 19 recordsLinked to original sources
PubMed1990

Immunolocalization of secretory protein-I or chromogranin A in amphibian urinary bladder granular cell granules.

The presence of secretory protein-I (SP-I) or chromogranin A (CGA) in granules isolated from the granular cells of the amphibian urinary bladder epithelium was investigated using ultraimmunohistochemistry. Granules were isolated by cell fractionation using Percoll density gradients. SP-I was isolated and purified from bovine parathyroid glands. Antibodies were raised in rabbits and purified by affinity chromatography. Ultraimmunocytochemistry, employing the avidin-biotin-peroxidase (ABC-complex) procedure, was used to localize SP-I on thin sections of isolated granules. About 27% of the granules from control (-ADH) cells were SP-I+, while 51% of the granules fractionated from hormone treated (+ADH) cells were positive for this protein (p less than 0.0001). Accordingly, granules from ADH-treated cells also showed a significant (p less than 0.0001) increase in total protein.

Animals↗
PubMed1984

[Histological subtypes of bronchial carcinoma and their biological behavior].

The WHO classification of pulmonary tumors, Geneva 1981, is used to describe the biological and morphological characteristics of the various types of bronchial tumors. The differences in frequency are noted for clinical biopsy material and autopsy statistics for squamous-epithelium cancers and small-cell bronchial carcinomas. The latter are incorrectly seen as undifferentiated cancers. Their particular hormonal activity and leading role among the hormone-producing lung tumors is emphasized. Their relationship to the carcinoids is also discussed briefly. The causes of the relatively common adrenal metastases are listed. The biological-morphological characteristics of the adeno- and bronchiolo-alveolar cancers, as well as of the giant-cell carcinomas, are mentioned.

Carcinoid Tumor↗
PubMed1979

Endocrine-amphicrine enteric carcinoma of the nasal mucosa.

A 39-year-old bus driver had been suffering for 2 years from a malignant polypoid mucosal proliferation of the upper nasal concha-ethmoid region, resembling a highly differentiated, villous-glandular adenocarcinoma of enteric type. There were numerous mono- and amphicrine cells and a massive quantity of oxyphilic, frequently Paneth-like goblet cells in the tumor. Immune-histochemically, a number of gastrin- and fewer glucagon-positive cells were identified. The somatostatin level in the serum was clearly increased. Electron-microscopically, 7 different endocrine cell types were identifiable, in order of decreasing frequency: A-like- and G-cells, both types of 5-HT-cells, A-cells, EG- and K-cell-like elements. Particularly impressive were the muco-argyrophilic amphicrine cells, containing A-granules. The unusual enteric character of the carcinoma seems to result from boundary movements and tissue displacements in an ecto-entodermal embryonic border region. There was no history of occupational wood dust inhalation.

Adenocarcinoma↗
PubMed1979

Limits of therapy for malignant chorioepithelioma.

Report on two cases of malignant chorio-epithelioma following hydatidiform mole, both decreased 4 years after inception of the disease despite initially successful therapy and repeated remissions. In the first case a solitary pulmonary metastasis showing obvious de-differentiation and extensive local reparative processes was removed operatively. Associations to cytostatic medication are discussed. The second case was characterized by unusually extensive chronic pulmonary embolism with highly regressive choriocardinomatous aggregates. Death resulted unexpectedly from chronic dextrocardial insufficiency. It is stressed that the treatment is subject ot limitations of not only relative (i.e., resistance to cytostatics, inadequate treatment etc.) but also of an absolute nature, as in case 2.

Adult↗
PubMed1977

Leukemic nodules in the eye in immature-cellular infantile leukoses.

Two boys, aged 5 1/4 and 10 1/4, respectively, with acute immature-cell leukosis, died of massive cerebral haemorrhage. Their eyes showed extensive leukaemic involvement of the retina with development of numerous miliary leukaemic nodules; the vitreous of case 2 was also involved. The lesions were considered to have developed because of high circulating white cell counts, a tendency of blast cells to produce nodules, an oxygen poor avascular matrix in which to grow, and a physical environment which permitted growth without haemorrhage or distortion due to tissue pressures etc. Using histological methods, an attempt is made to trace the pattern of formation of the nodule, from an initial growing focus through "colonial" form resembling a bacterial colony to lysis. Necrotic blast cells are apparently a metabolic source for viable tumour cells. Their localization in the eye makes access by cytotoxic drugs difficult; thus they should be considered as blast cell pools.

Acute Disease↗
PubMed1977

[Fatal cerebral apoplexy as the first manifestation of immature infantile leukemia (author's transl)].

Among 93 clinical cases of mature and immature leukemia among children in the last 10 years only 3 showed massive cerebral hemorrhage as the first manifestation. The children--aged 5 3/12 yr., m., 2 1/12 yr., f., and 10 3/12 yr., m. died within 40, 48 and 7 h, respectively. Characteristically, an extreme hyperleukocytosis of immature cells with 8999000, 585000, and 360000 cells/mm3, respectively was found. Morphologically the quantitatively varying occurrence of blasts in veins and arteries, basically of hemodynamic origin, is notable, while locally pronounced variations in the venous involvement apparently are strongly dependent upon endovasal growth periods of the blasts. The blasts penetrated extravasal areas not only via passive but also via active migration. The mainly round to oval shape of the perivascular infiltrates of blasts is determined especially by the Virchow-Robins' spaces. The abscence of growth disrupting hemodynamics and texture structures in the unhindered areas of the cerebral ventricle system and retinal detachement favors the formation of leukemic nodules. Neurological symptoms accompanying a high blast count point to a diagnosis of intracerebral hemorrhage.

Acute Disease↗
PubMed1977

[Right atrial fibroma simulating cyanotic cardiac vitium in a newborn (author's transl)].

The clinical picture in a cyanotic newborn suggests pulmonary atresia or tricuspid atresia. Angiocardiography shows a right atrial tumor, at necropsy a ping-pong-ball sized fibroma is found. Hypoxia and congestive heart failure occurred and the baby died on his eleventh day of life. Uncertain cardiac symptomatology should always raise the suspicion of a cardiac tumor. Cardiac tumors with predominant intramural growth can show pure cardiomegaly- and/or cardiac arrhythmias, congestive failure, while intracavitary growth may lead to various kinds of in- and outflow obstruction and/or embolisations.

Cyanosis↗
PubMed1976

[Intrapulmonary fibromas (author's transl)].

Based on 5 individual cases over a period of 8 years (1 fibroma, 1 angiofibroma, 2 adenofibromas, 1 xanthous neurofibroma) the characteristics of the rare intrapulmonary fibroma and the therapeutic consequences are discussed. Any suspicious tumor demands a thoracotomy with careful preoperative treatment and the subsegment or segment resection depending on the histological diagnosis reported during the procedure.

Adenofibroma↗
PubMed1975

Congenital stalked fibromatous polyp of the superior pole of the tonsil containing hairless sebaceous glands.

A polyp of the size of a small bean was discovered incidentally on the superior pole of the right tonsil of a 29-year-old man. Morphologically it bore a considerable resemblance to the immature infantile variant of the sebaceous-gland nevus, the Naevus epitheliomatosus sebaceus Wolters, but its top was mature. The polyp is viewed as a congenital dysontogenic tumor which, owing to its fibromatous basis, lack of hair, and its immature and mature sebaceous glands, may be informally classified as a "missing link" between the haired pharyngeal polyp and the pure pharyngeal fibroma.

Adult↗