Biomedical subjects

K O'Hagan

Publications and source records attributed to K O'Hagan.

2 recordsLinked to original sources

PubMed1984

Detection of hybridomas secreting monoclonal antibodies to human gamma interferon using a rapid screening technique and specificity of certain monoclonal antibodies to gamma interferon.

An immunoprecipitation technique, which uses radiolabeled human gamma interferon (HuIFN-gamma) and a sheep anti-mouse F(ab')2 serum, is described for the rapid detection of mouse monoclonal antibodies to IFN-gamma in hybridoma culture supernatants. This technique which can be performed in 4 h detects both neutralizing and nonneutralizing antibodies to IFN-gamma. Certain monoclonal antibodies prepared against natural (glycosylated) IFN-gamma which neutralized the antiviral activity of natural IFN-gamma bound strongly to rDNA (unglycosylated) IFN-gamma derived from E. coli, but failed to neutralize its antiviral activity.

Animals↗

PubMedDate not supplied

Cholangiocarcinoma: a nursing perspective.

Primary cancer of the bile duct (cholangiocarcinoma [CC]) is a rare malignancy that presents many nursing challenges. This article focuses on disease presentation, treatment options, quality of life, and the nurse's unique role in caring for this patient population. Surgical resection is the only treatment modality that offers a potential cure and prolonged survival. In patients with unresectable disease, biliary bypass or nonoperative biliary drainage procedures can provide palliation. Other palliative treatment modalities include chemotherapy, radiation, and photodynamic therapy. The sudden onset, limited treatment options, and overall poor prognosis add to the challenge of caring for patients with CC.

Bile Duct Neoplasms↗