[Hemorrhagic diathesis caused by mesenchymo-capillary changes in patients with bronchial asthma chronically treated with triamcinolone acetonide].
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Biomedical subjects
Publications and source records attributed to K Obtułowicz.
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Examinations were done in 22 patients suffering from bronchial asthma and 10 patients with acute respiratory infection (control group). In all cases quantitative mycological and bacteriological sputum tests, mycoserological tests and cutaneous tests were performed. Presence of C. albicans was evident in 90% of sputum from asthmatics with proliferation in 45% of cases (10(4) or more of yeast cells/ml of sputum). The proliferation of the mould fungi in the sputum was not observed. Allergization with C. albicans was encountered in 25% of asthmatics and allergization with mould fungi in 36% of them. Mycoserological tests were reliable when the autoantigens of the patients flora were used. The studies of the control group call attention to possible accompanying acute invasions of C. albicans in the early days of primary acute respiratory tract infection.
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The study material consisted of 18 patients (10 men, 8 women, aged 26-66 years), suffering from recurrent nasal polyps and bronchial asthma. Nine patients manifested intolerance to aspirin and non-steroid anti-inflammatory drugs (NSAIDs). The polyps removed during one of polypectomies were analysed with the help of scanning electron microscope (SEM) in order to evaluate the morphology of their surface. All the specimens displayed the increase in areas of cilium-free epithelium, covered with short microvilli and squamous epithelial cells. The arrangement of these changes was irregular and they were more pronounced in patients with intolerance to aspirin and NSAIDs. Apart from this, there were no other differences which would allow to differentiate in SEM investigation between polyps derived from patients with and without tolerance to NSAIDs.
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Catalet is the Polish vaccine against pollinosis. It contains pollens of 13 species (mainly grass) and is used in the treatment of pollinosis. It is standardized in protein units. Allergen adsorption on aluminium hydroxide prolongs its absorption and decreases a number of the necessary injections. A four-year investigations in 30 patients (including 5 children) showed that Catalet tolerability is comparable with that of foreign-made preparations such as Alavac P, Desalerga F, and Allpyral-5 Grass mix.