Biomedical subjects

K Ochsner

Publications and source records attributed to K Ochsner.

3 recordsLinked to original sources

PubMed2000

Intraocular lens glucose sensor.

Ocular spectroscopy, which is the use of the eye to monitor optically the concentration of metabolites in the body, has been successfully applied to monitor aqueous humor glucose concentration. In the United States, 1.7 million intraocular lenses are currently implanted yearly. Because patients with diabetes are more likely to develop cataracts at an earlier age, a relatively high proportion of the patients receiving intraocular lenses have diabetes. Last year, 110,000 patients with diabetes received intraocular lens implants of various materials. We have successfully polymerized a fluorescent complex within a hydrogel intraocular lens that responds well to glucose concentration.

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PubMed1987

Qualitative radiographic diagnosis of osteo-arthritis of the knee joint in the C57BL mouse.

Experiments were performed to assess the diagnostic value of radiography in osteo-arthritis (OA) of the knee joint in C57Bl mice. Comparative histological and radiographic examination of knee joints from 96 animals showed that if the classical diagnostic criteria (narrowing of the joint space, sclerosis of the subchondral bone, deformation of the joint epiphyses) are applied, OA is not readily detectable by radiography. If these criteria are extended to include radiographic changes in the menisci (enlargement, deformation, increased and/or heterogeneous density), the frequency of detection is much improved. However, except in the severest forms of OA, radiography does not afford a satisfactory means of distinguishing between various degrees of severity. The qualitatively evaluated data nevertheless do suggest that quantitative radiographic diagnosis of OA of the murine knee joint may be useful, both for improving the detection rate and for discriminating various degrees of OA.

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PubMedDate not supplied

[Etiopathogenetic significance of bone changes in spontaneous gonarthritis in the mouse].

In the C57 Black, STR/IN and MAGf strains of mice, which are prone to develop spontaneous osteo-arthritis of the knee, histomorphological examinations were made of the osseous parts of the joint. It was found that the number of animals with osteo-arthritis and with degenerative changes in the epiphyseal growth zone increases with age. There is nevertheless evidently no interrelation between the two phenomena. The same applies to the occurrence of osteoporosis and degenerative joint disease, since male C57 Black mice, for example, develop osteo-arthritis of the knee relatively often, but develop osteoporosis much more rarely, while the opposite is observed in the females. Moreover, among the juvenile joint degenerations in the STR/IN and MAGf strains, a high percentage of osteo-arthritis of the knee is found, but only a few instances of osteoporosis. The majority of the (relatively rare) idiopathic condylar necroses coincide with osteo-arthritis of the knee, but not vice versa. The development of osteosclerosis and degenerative cartilaginous defects is mostly (possibly always) a sequela and not the cause of osteo-arthritis of the knee. Malpositions are often associated with the development of osteo-arthritis of the knee. The C57 Black strain exhibits a certain tendency to develop genu valgum, and the STR/IN strain almost regularly shows genu varum; no distinct tendency is detectable in MAGf mice. Like the osteophytes, the enlarged menisci with obligatory ossification centres invariably seen in conjunction with osteoarthritis apparently help to compensate for the condylar incongruence caused by the degenerative process, prevent partial dislocations, and hence improve the stability of the joint.

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