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Biomedical subjects

K Oh

Publications and source records attributed to K Oh.

At least 19 recordsLinked to original sources
PubMed2007

Effects of a p38 MAP kinase inhibitor on bone ingrowth and tissue differentiation in rabbit chambers.

The effects of an oral p38 mitogen-activated protein kinase (MAPK) inhibitor and polyethylene particles separately and together on tissue differentiation in the bone harvest chamber (BHC) in rabbits over a 3-week treatment period were investigated. The harvested tissue was analyzed histomorphometrically for markers of bone formation (percentage of bone area), osteoblasts (alkaline phosphatase staining), and osteoclasts (CD51, the alpha chain of the vitronectin receptor). Polyethylene particles decreased the percentage of bone ingrowth and staining for alkaline phosphatase. The p38 MAPK inhibitor alone decreased alkaline phosphatase staining. When the oral p38 MAPK inhibitor was given and the chamber contained polyethylene particles, there was a suppression of bone ingrowth and alkaline phosphatase staining. In contrast to oral non-steroidal anti-inflammatory drugs (NSAIDs) and local Interleukin-1 receptor antagonist (IL-1ra) administration, the oral p38 MAPK inhibitor alone did not suppress bone formation when given during the initial phase of tissue differentiation. Particle-induced inflammation and the foreign body reaction were not curtailed when the p38 MAPK inhibitor was given simultaneously with particles. Additional experiments are needed to establish the efficacy of p38 MAPK inhibitor administration on mitigating an established inflammatory and foreign body reaction that parallels the clinical situation more closely.

Administration, Oral↗
PubMed2006

Versatile control of geometric birefringence in elliptical hollow optical fiber.

A novel optical fiber fabrication technique was developed by converting the symmetry of the silica substrate into the germanosilicate ring core to efficiently introduce geometric birefringence in an elliptical hollow optical fiber. Due to high ellipticity in the hollow ring core, the fiber provides an extremely high group birefringence of 2.35 x 10(-3) at 1550 nm. Single-mode single-polarization guidance was also experimentally confirmed, with a bandwidth of approximately 35 nm. The generic adiabatic mode conversion capability in the taper also provided a stable fusion splice to conventional single-mode fiber with low loss and high tensile strength.

Journal Article↗
PubMed2006

Fiber-optic color synthesizer.

Full-color synthesis was achieved, for what we believe is the first time, utilizing a novel 3x1 hard polymer-clad fiber coupler along with red, green, and blue (RGB) LED primaries. By using RGB LEDs that are coupled to three input ports, the device rendered full color from the output port with a circular emitting pixel of 135 microm in diameter with an extended color gamut. The proposed fiber-optic color synthesizer can provide a compact waveguide solution for the beam scanning display and the tunable pure white source for LED backlighting.

Journal Article↗
PubMed2006

Highly polarization-dependent periodic coupling in mechanically induced long period grating over air-silica fibers.

A very flexible and versatile tunable mechanical grating platform is introduced, with which highly polarization-dependent mode coupling is observed for three types of air-silica microstructured fibers: hollow core fiber, hexagonal-boundary holey fiber (HHF), and circular-boundary holey fiber. The resonances of gratings showed highly polarization-dependent broadband coupling compared with conventional single-mode fibers due to their unique beat-length dispersions between the core and the cladding modes, which could find applications in wideband polarization-dependent loss compensation. We further present significance of the spatial symmetry of HHF in distinct mode coupling for different rotation angles around the fiber axis.

Journal Article↗
PubMed2006

Defect and lattice structure for air-silica index-guiding holey fibers.

We propose new design parameters for index-guiding holey fiber that can provide flexibility in defect and lattice design and adiabatic mode transformation capability. The new defect consists of a central air hole and a germanosilicate ring surrounding it, which results in a large-area annulus mode profile, low splice losses to standard fiber, 0.7 dB at 1.55 microm, and chromatic dispersion with a low slope, 0.002 ps/km nm2.

Journal Article↗
PubMed2005

Multiport N x N multimode air-clad holey fiber coupler for high-power combiner and splitter.

We report 2 x 2 and 4 x 4 multimode air-clad holey fiber couplers fabricated by a novel fusion and tapering technique. The devices showed excellent port-to-port coupling uniformity over a wide spectral range of 800-1650 nm. The 4 x 4 coupler showed a low insertion loss of 9.9 dB and excess loss of 3.9 dB at 1310 nm. Because of its unique air cladding and the high numerical aperture of the holey fiber structure, the device showed strong potential in high-power applications.

Journal Article↗
PubMed2005

Bandwidth control in a hybrid fiber acousto-optic filter.

We report a bandwidth variation technique in an acousto-optic filter. Utilizing the adiabatic conversion in both optical and acoustic modes, we obtain a novel hybrid waveguide composed of serial concatenation of single-mode fiber (SMF) and two-mode hollow optical fiber (HOF). On the basis of dissimilarity in the phase-matching conditions and beat-length dispersion in SMF and HOF, the FWHM of the resonant bands is varied from 3.8 to 190 nm near the 1.5-microm region in a single device. Furthermore, we theoretically analyze the acousto-optic coupling among the guided modes in HOF, which shows good agreement with experimental observations.

Journal Article↗
PubMed2004

In-line polarization controller that uses a hollow optical fiber filled with a liquid crystal.

We demonstrate an in-line polarization controller based on a hollow optical fiber filled with a nematic liquid crystal by fabricating thin-film electrodes on the cladding of a fiber. The polarization controller consists of three control sections with fixed optic axes, which operate as phase retarders. The phase retardation in each section is controlled by the magnitude of the applied electric field. The full wave retardation voltage of the polarization controller is approximately 85 V.

Journal Article↗
PubMed2003

Broadband amplified spontaneous emission from an Er(3+)-Tm(3+)-codoped silica fiber.

A new type of amplified spontaneous emission (ASE) based on an Er-Tm-codoped silica fiber is reported. When the fiber was pumped at 980 nm, the emission yielded a 3-dB bandwidth over 90 nm (1460-1550 nm) without any external filters, which is twice larger than that produced by conventional Er-doped fiber ASE sources. We believe that the superposition of two ASE bands, one from Er ions near 1530 nm and the other from Tm ions near 1450 nm, results in the broad bandwidth. Temperature-dependent ASE powers and fiber-length-dependent spectra strongly suggest that photon-assisted energy transfer between the sensitizing ion, Er, and the acceptor ion, Tm, plays an important role in changes in the bandwidth's size.

Journal Article↗
PubMed2001

Multiple pathways governing Cdx1 expression during murine development.

Cdx1 encodes a mammalian homeobox gene involved in vertebral patterning. Retinoic acid (RA) is likewise implicated in vertebral patterning. We have previously shown that Cdx1 is a direct retinoid target gene, suggesting that Cdx1 may convey some of the effects of retinoid signaling. However, RA appears to be essential for only early stages of Cdx1 expression, and therefore other factors must be involved in maintaining later stages of expression. Based on function and pattern of expression, Wnt family members, in particular Wnt3a, are candidates for regulation of expression of Cdx1. Consistent with this, we confirm prior results which demonstrated that Cdx1 can be directly regulated by Wnt signaling, and identify functional LEF/TCF response motifs essential for this response. We also find that Cdx1 expression is markedly attenuated in a stage- and tissue-specific fashion in the Wnt3a hypomorph vestigial tail, and present data demonstrating that Wnt3a and RA synergize strongly to activate Cdx1. Finally, we show that Cdx1 positively regulates its own expression. These data prompt a model whereby retinoid and Wnt signaling function directly and synergistically to initiate Cdx1 expression in the caudal embryo. Expression is then maintained, at least in part, by an autoregulatory mechanism at later stages.

Animals↗
PubMed2001

Idiopathic juxtafoveal retinal telangiectasis: case report and literature review.

BACKGROUND: Idiopathic juxtafoveal retinal telangiectasis (IJRT) is an uncommon cause of vision loss. It is characterized by irregularly dilated capillaries in the macula, often found temporal to the fovea and straddling the horizontal raphe. These telangiectatic vessels appear similar to microaneurysms and can be difficult to detect without fluorescein angiography. Varying degrees of vessel leakage and exudation are also common features. Three distinct types of IJRT have been described on the basis of clinical features. Within the spectrum of disease encompassed by IJRT, it can affect either gender--present unilaterally or bilaterally--and occur at any age. CASE REPORT AND REVIEW: Presented here is a case with type 1A idiopathic juxtafoveal retinal telangiectasis and a review of all types.

Diagnosis, Differential↗
PubMed1999

Douching: a problem for adolescent girls and young women.

OBJECTIVE: To compile available published data on the prevalence of douching practices in adolescent girls and young women and the effects of douching on gynecologic health, including studies of gynecologic changes due to douching in adolescent girls and young women, surveys that demonstrated the prevalence of douching in the populations, and policy statements or lack thereof from professional and medical organizations with regard to the practice of douching. DATA SOURCES: We did Internet searches, including a MEDLINE search, a literature review, and used the telephone, mail, and e-mail to contact professional organizations. RESULTS: Douching has been found to be strongly associated with increased risk for pelvic inflammatory disease, bacterial vaginosis, and ectopic pregnancy, the former of which is especially prevalent in adolescent girls and young women. Douching is practiced by 15.5% of adolescent girls and young women in the United States, with significantly higher prevalences in certain groups in the population. We have not found any official position of professional and medical organizations on the practice of douching. CONCLUSIONS: Because vaginal douching has been shown to be associated with bacterial vaginosis, pelvic inflammatory disease, and ectopic pregnancy, and because no benefits are conferred on those who practice it, douching should be discouraged among adolescent girls and young women. There is a great need for further studies, particularly prospective ones, to determine if there is evidence of a direct causative influence of douching on pelvic inflammatory disease, ectopic pregnancy, and/or bacterial vaginosis, and to determine why adolescent girls and young women douche.

Female↗
PubMed1998

Correlation between endoscopic severity and the clinical activity index in ulcerative colitis.

OBJECTIVE: The aim of this study was to examine the relationship between a new activity index and the endoscopic severity assessed by sigmoidoscopy in patients with ulcerative colitis. METHODS: We evaluated the sigmoidoscopic severity and Activity Index (AI) in 37 patients with distal colitis, 23 with left-sided colitis, and 36 with total colitis, in which the severity was divided into three categories: grade 1 = mildly active, grade 2 = moderately active, and grade 3 = severely active. We examined the relationship between the AI or clinical parameters and the endoscopic severity in all 96 cases. RESULTS: The AI was found to be significantly correlated with the degree of sigmoidoscopic activity in all cases, as well as in those with distal colitis, left-sided colitis, or total colitis. When patients with both grade 1 sigmoidoscopic activity and AI values of less than 150 were regarded to have mild colitis and patients with either grade 2 or grade 3 sigmoidoscopic activity and AI values of more than 150 were regarded to have moderate or severe colitis, 10 of 37 (27%) in the distal colitis, one of 23 (4.3%) in the left-sided colitis, and four of 36 (11.1%) in the total colitis groups were thus misclassified regarding the distinction between mild colitis and moderate or severe colitis. Three of four patients with severity of grade 1, indicating AI values of more than 150, had total colitis, whereas the remaining one had left-sided colitis. On the other hand, 10 of 11 patients with severity of grades 2 or 3 with AI values of less than 150 had distal colonic involvement. When the endoscopic activity was equivalent, the highest mean AI values occurred in total colitis whereas the lowest mean AI values were found in distal colitis. CONCLUSIONS: The AI well reflects the sigmoidoscopic activity. High AI values with a low sigmoidoscopic severity are thus considered to reflect extensive involvement, whereas a high sigmoidoscopic severity with low AI values is thought to indicate the involvement of the distal colon.

Adolescent↗
PubMed1997

Case report: eosinophilic colitis with high antibody titre against Ascaris suum.

Eosinophilic gastroenteritis (EGE) is an inflammatory disease characterized by eosinophilic infiltration of the gastrointestinal tract accompanied by varying abdominal symptoms and usually by peripheral blood eosinophilia. Although the precise aetiology of EGE remains to be determined, contribution of allergic process to certain allergens, such as foods, drugs and parasites, has been repeatedly proposed as the pathogenesis of the disease. Here we report on a rare case of a woman who had extensive eosinophilic infiltration in the descending and rectal colon with a high titre of IgG antibody against Ascaris suum. The patient was successfully treated with prednisolone.

Animals↗
PubMed1996

An in vitro assay for detection of glomerular binding IgG autoantibodies in patients with systemic lupus erythematosus.

The deposition of anti-dsDNA antibodies in the glomerulus is believed to play a critical role in the pathogenesis of nephritis in SLE. However, an absolute correlation between serum levels of anti-dsDNA antibodies and renal disease has not been found. Recently a glomerular binding assay (GBA) has been developed to detect IgG binding to isolated rat glomeruli. We have used the GBA to study sera from four groups of SLE patients: (A) + anti-dsDNA antibodies, active nephritis; (B) - anti-dsDNA antibodies, active nephritis; (C) + anti-dsDNA antibodies, no nephritis; and (D) - anti-dsDNA antibodies, no nephritis. The serum anti-dsDNA antibodies in group A and group C patients could not be distinguished on the basis of isotype, charge, or cross-reactivity with histones. Nevertheless, the mean intensity of glomerular immunofluorescence was significantly higher in group A than in the three other patient groups and distinguished between patients with serum anti-dsDNA antibodies who had nephritis and those without clinically apparent nephritis. GBA reactivity was unaffected by DNase treatment of sera, but was partially inhibited by preincubation with dsDNA. These findings are consistent with the hypothesis that some anti-dsDNA antibodies cross-react with glomerular components and that the presence of this cross-reactivity is associated with, and may be responsible for, the development of nephritis. In addition, we have identified a group of SLE patients with renal disease and typical renal histopathology and immune deposits who do not have serum anti-dsDNA antibodies or antibodies that directly bind to glomeruli in the GBA. The mechanism of renal immune deposition in these patients remains to be determined.

Autoantibodies↗