Biomedical subjects

K Ohtsu

Publications and source records attributed to K Ohtsu.

28 records · Page 2Linked to original sources

PubMed1985

A photoproduct with 13-cis retinal generated by irradiation with violet light in the octopus retina.

The photoconversion between rhodopsin (R) and metarhodopsin (MR) was investigated in the retina of Octopus ocellatus by measurements of the fast photovoltage (FPV) in conjunction with high pressure liquid chromatography (HPLC). Following conversion of most of R to MR by short-term exposure to an intense violet light, a large vitreous negative FPV due to photon absorption by MR was observed with an orange test flash. By continuing the exposure to the same violet light, however, the negative FPV became very small, though long-term irradiation with blue-green light produced a recovery. With the violet light exposure a substance other than R and MR is produced, which hardly contributes to FPV generation. Analysis of retinal isomers with HPLC show that such an exposure produces a substance with 13-cis retinal as its chromophore and that it was significantly reduced after exposure to blue-green light.

Animals↗

PubMed1985

Recent development of the study on clinical significance of abnormal eye movement.

As a general trend, the diagnosis in medical clinics often depends on laboratory test results. Neurotological diagnosis, however, requires detailed neurological examinations on a patient by a neurotologist. Therefore, there are differing diagnostic skills among physicians, and there is a kind of "man-made flavor" in neurotological diagnostic procedure. In the present study, current development in the knowledge on the clinical diagnostic significance of pathological eye movement during the last 2-3 years is summarized. Acquired pendular wondering eye-movement. Fixation jerks. Spontaneous and transitory eyeball burst or seizure. Vertical rebound nystagmus. Optokinetic vertical ocular dysmetria. Divergence nystagmus. Counterolling, pure rotatory positioning nystagmus. Inversion of optokinetic after-nystagmus (OKAN). Vertical congenital nystagmus and inversion of optokinetic nystagmus (OKN). Treatment of congenital nystagmus. Vertical spontaneous nystagmus to lower eyelid or so-called "downbeat nystagmus." Downbeat nystagmus seen in bilateral labyrinthine dysfunction. The significance of bilateral vestibular lesion, or symmetric lesion in other is emphasized in the present report for reader's reference and criticism. Our experience on the clinical significance of the abnormal eye movement was reported. It is our wish that accumulation of data on important cases along with the results of experimental studies directly connected with clinical medicine may contribute to the progress of our neurotology in the right direction as "neurology of the posterior fossa."

Cerebellar Diseases↗

PubMed1984

Vertical ocular dysmetria--vertical rebound nystagmus and optokinetic vertical ocular dysmetria.

Ocular dysmetria in vertical eye movement was confirmed by electronystagmographic recording in 100 cases. Ocular dysmetria in spontaneous vertical ocular movement was reported in seven cases. It can be called vertical rebound nystagmus. This phenomenon was more prominent in vertical movement of the eyes returning from upward gazing to mid-position than in the movements of downward gazing. Optokinetic vertical ocular dysmetria induced by vertical optokinetic stimulation was observed in 93 cases. This phenomenon was far more prominent in upward optokinetic nystagmus than in downward optokinetic nystagmus. The pattern of optokinetic vertical ocular dysmetria was classified into the following four types: the dysrhythmic type, the overshoot type, the ataxic type and the saccadic (semi-inversive) type. The pathophysiological mechanism of horizontal ocular dysmetria should be different from the mechanism of vertical ocular dysmetria.

Adult↗

PubMed1983

UV-visible antagonism in extraocular photosensitive neurons of the anthomedusa, Spirocodon saltatrix (Tilesius).

Attempts were made to identify extraocular photosensitive cells in the subtentacular region (the area between the ocelli and the nerve ring) and around the inner-nerve ring of the anthomedusan Spirocodon saltatrix. Irradiation with ultraviolet light (UV) led to inhibition of spontaneous impulses and after UV-off, an afterinhibition which lasted for a few minutes. This afterinhibition was rapidly overcome by exposure to visible light (VIS). UV-VIS antagonism of this type was identified in six different impulse systems monitored in extracellular recordings. Intracellular recordings from two of the six cell types showed that UV irradiation causes hyperpolarization which inhibits spontaneous activity. The other cell types showed no membrane potential changes during UV irradiation even though the cells' spontaneous outputs were inhibited. It was concluded that the photosensitivity lies in three kinds of nerves which are distributed widely through the subtentacular region and the nerve ring.

Animals↗

PubMed1981