Oral dose of enalapril or captopril moderately reduced the blood pressure of the spontaneously hypertensive rats (SHR) but not those of normotensive rats. The single daily dose of captopril (30 mg/kg) produced antihypertensive response equivalent to enalapril (3 mg/kg). Chronic administration of these drugs for 2 weeks revealed that systolic blood pressure was reduced more by captopril than enalapril. We did not find differences in hypotensive activity between Enalapril IF and Renitec Merck as well as Captopril JZF Polfa and Capoten Squibb.

Administration, Oral↗

PubMedDate not supplied

Cardiovascular action of a new carbenoxolone derivative.

The circulatory effects of oleanoic acid sodium hydrogen succinate (OSS), an analogue of the anti-ulcer drug, carbenoxolone, were investigated. As carbenoxolone produces such adverse effects as sodium retention and a subsequent elevation of the arterial blood pressure in man, the present study was aimed at determining whether OSS is similar or different from it in this respect. Carbenoxolone, (43,3 mg/kg po) and OSS (66,6 mg/kg po) were given to rats twice daily for 4 weeks. The systolic blood pressure was elevated already after the first week of treatment. The hypertension was accompanied by bradycardia, which increased with the time of treatment. In the blood an increase in the creatinine level, a decrease in the urea level, and a slight elevation in sodium concentration were found after the treatment, while the potassium concentration during the whole treatment period (4 weeks) remained unchanged. Although the principal aldosterone-like effects of carbenoxolone were attributed to the oxygen presence in position 11 of the glycyrrhetinic acid ring, [8], the absence of an oxygen at that position in OSS did not cause the loss of the adverse circulatory effect.

Animals↗

PubMedDate not supplied

Synthesis and some biological properties of new derivatives of 1-S-phenylthioglycolonitrile.

A series of new S-phenylthioglycolic acid derivatives was synthetized via common transformations of alkylated S-phenyl-thioglycolonitrile. The compounds were submitted to pharmacological screening. N,N-Diethylaminoethyl ester of 1-S-phenylcyclopentane carboxylic acid was submitted to detailed studies and showed high local anesthetic properties.

Anesthetics, Local↗

PubMedDate not supplied

[Some pharmacologic properties of a new compound blocking the autonomic ganglia].

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Animals↗

PubMedDate not supplied

[The comparative studies on the influence of persantin on the coronary circulation in dogs and rabbits].

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Animals↗

PubMedDate not supplied

Assessment of haemodynamic changes and acid-base equilibrium during hypovolaemia and after infusion of plasma substitutes in dogs.

The following haemodynamic values were determined in anaesthetized mongrel dogs: heart rate, systolic blood pressure in the ascending aorta, left ventricular pressure at the peak dp/dt, left ventricular end-diastolic pressure, time interval from Q in ECG to the onset of the systolic wave of dp/dt, time interval from Q in ECG to peak dp/dt, maximum rate of left ventricular pressure rise, femoral arterial flow, and certain indices of left ventricular contractility. It was concluded from the results of these experiments that infusion of a modified gelatin solution Fluigel prevented haemodynamic and metabolic changes produced by experimental hypovolaemia more effectively than infusion of Plasmagel.

Acid-Base Equilibrium↗

PubMedDate not supplied

Relationship between hemodynamic changes and endogenous catecholamine release caused by a new antiarrhythmic agent, AB-2, in cats and dogs.

An antiarrhythmic agent, AB-2, given iv produced in cats and dogs a biphasic action on blood pressure: rapid and short-lasting hypertension followed by depression of blood pressure. The first phase was accompanied by a sharp rise of serum catecholamines (6-fold increase in adrenaline, and 4.5-fold increase in noradrenaline level) and of indices of left ventricular contractility. These effects were more pronounced in cats than in dogs. In cats, but not dogs, the biphasic effect was observed also after po administration. The elevated endogenous catecholamine release was not accompanied by an increase in plasma 11-hydroxycorticosteroids levels.

11-Hydroxycorticosteroids↗

PubMedDate not supplied

Hypotensive effect of clonidine and regional noradrenaline concentration in the brain of normotensive and hypertensive rats after acute and long-term treatment.

The following experiments were performed: a) the effects of increasing doses (0.025-0.2 mg/kg p.o.) of clonidine on the blood pressure and heart rate in SHR and normotensive rats (acute treatment), b) the influence of an effective dose (0.05 mg/kg) of clonidine on the same parameters during 3-week administration, c) the effect of clonidine (0.05 mg/kg) on tissue noradrenaline (NA) concentration in the medulla, striatum and hypothalamus after acute and long-term treatment of SHR and normotensive rats. The experiments were carried out on unanaesthetized animals. Blood pressure and heart rate were measured by on indirect method. Tissue NA was assayed fluorimetrically. Clonidine in a single dose caused a significant fall of blood pressure and heart rate. These effects were much more pronounced in SHR. The effective dose (0.05 mg/kg) in acute experiments was ineffective in long-term (3 weeks) treated rats. This dose of clonidine had no detectable effect on regional NA concentration in rat brain with the exception of the hypothalamus where the concentration of NA was markedly increased (SHR in acute experiments).

Animals↗

PubMedDate not supplied

The effect of a new antidepressant drug, C-45, and imipramine on some hemodynamic parameters in the dog.

C-45, given to dogs in doses corresponding to 1/30 and 1/10 of LD50 iv, slowed down the cardiac rhythm and depressed systolic, diastolic, and end-diastolic pressures in the left ventricle. A dose of 1/30 of LD50 slightly increased, and a dose of 1/10 of LD50 depressed the indices of contractility of the cardiac muscle. Imipramine produced similar effect but accelerated the cardiac rhythm, and when used in a dose of 1/10 of LD50, it impaired atrioventricular and intraventricular conduction.

Animals↗

PubMedDate not supplied

Influence of coenzyme Q-10 on the hypotensive effects of enalapril and nitrendipine in spontaneously hypertensive rats.

Administration of coenzyme Q-10 (10 mg/kg) once a day for 4 weeks decreased the arterial blood pressure in SHR's. Enalapril and nitrendipine administered in a single dose caused significant decrease of blood pressure. Application of enalapril and nitrendipine to rats chronically pretreated with coenzyme Q-10 revealed, that the maximal hypotensive effect was not greater, but it lasted much (ca. 2-times) longer. Independently of mechanism of this interaction it may be suggested that the chronic administration of coenzyme Q-10 would create the possibility of significant decrease of the frequency of some antihypertensive drug administration.

Animals↗

PubMedDate not supplied

Biosynthesis of catecholamines, uptake of 3H-noradrenaline, and reactivity of cardiovascular system of the rat after chronic and acute treatment with a new antidepressant agent, IPF C-45.

The effect of acute and chronic treatment of rats with IPF C-45 on the following biochemical and pharmacological parameters was tested: catecholamine concentration in brain, heart and adrenals, 3H-noradrenaline uptake by cardiac muscle, the action on catecholamine synthesis following treatment with alpha-methyl-p-tyrosine, reactivity of cardiovascular system to catecholamines and isoproterenol-induced tachycardia. Given chronically, IPF C-45 does not affect noradrenaline uptake by the cardiac muscle. Both chronic and acute administration of the drug decelerates catecholamine biosynthesis by inhibition of tyrosine hydroxylase activity. It seems that the action of IPF C-45, a benzonaphthyridone derivative, affects catecholamine metabolism in a manner distinctly different from that of tricyclic antidepressant drugs.

Adrenal Glands↗