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K Omiya

Publications and source records attributed to K Omiya.

24 records · Page 2Linked to original sources
PubMed1993

Prediction of exercise tolerance in the chronic phase of myocardial infarction by using ventilatory gas analysis.

To predict exercise tolerance in the chronic phase of myocardial infarction (MI), cardiopulmonary exercise testing was performed using a ramp treadmill protocol in 25 patients at 1 and 3 months after the onset of MI. Oxygen uptake, heart rate and O2 pulse were estimated at rest, during a warm-up period, and at the levels of anaerobic threshold (AT), respiratory compensation (RC) and peak exercise. Results were as follows: 1) AT and peak oxygen uptake at 3 months after the onset of MI were 14.1 +/- 2.8 and 21.8 +/- 5.2 ml/min/Kg, respectively. 2) The subjects were divided into 2 groups according to peak oxygen uptake at 3 months: one showing peak oxygen uptake > 22 ml/min/Kg and the other < 22 ml/min/Kg. The former group (n = 13) was referred to as the good tolerance group, and the latter group (n = 12) was referred to as the poor tolerance group. Oxygen uptake at AT, RC and peak exercise was lower in the poor tolerance group than in the good tolerance group (11.2 vs 14.7, 15.1 vs 20.4, 17.1 vs 23.4 ml/min/Kg, respectively). 3) The increases in oxygen uptake from AT to RC and from AT to peak exercise were less in the poor tolerance group than in the good tolerance group. 4) O2 pulse at rest, warm-up, AT, RC and peak exercise were also lower in the poor tolerance group.2+ tolerance in the chronic phase of MI.

Aged↗
PubMed1990

Dopamine D-1 but not D-2 receptor stimulation of the dorsal striatum potentiates apomorphine-induced jaw movements in rats.

The effects of bilateral injections of selective D-1 and D-2 agonists and antagonists into the dorsal striata on apomorphine-induced jaw movements were studied in ketamine-anaesthetized rats after C1 spinal transection. A phototransducer attached to the lower mandible automatically detected jaw movements. YM-09151-2 (0.2 and 0.5 micrograms) and cis(Z)-flupentixol (0.5 and 1 microgram) injected into the dorsal striatum increased the frequency of jaw movements after apomorphine (0.2 mg/kg i.v.). The effects were prevented by administration of SCH23390 (1 microgram) with YM-09151-2 (0.5 microgram) or cis(Z)-flupentixol (1 microgram). Injection of SCH23390 (1 microgram) alone into the dorsal striatum failed to alter the apomorphine (0.5 mg/kg i.v.)-induced jaw movements. Local application of the selective D-1 agonists, SKF38393 (5 micrograms) and SKF75670 (10 micrograms), into the dorsal striatum potentiated the apomorphine (0.2 mg/kg i.v.)-induced jaw movements, while a D-2 agonist, quinpirole (10 micrograms), injected into the same site attenuated these movements. These data are suggestive of an oppositional D-1: D-2 receptor interaction in the dorsal striatum.

2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-ben↗
PubMed1988

Ketamine anaesthesia has no effect on striatal dopamine metabolism in rats.

Striatal levels of dopamine (DA), 3,4-dihydroxyphenylacetic acid and homovanillic acid in rats were not altered for at least 6 h after a ketamine injection (100 mg/kg). Striatal DA turnover which was measured by giving alpha-methyl-p-tyrosine after ketamine was unchanged. Even the dose regimen of ketamine which anaesthetized animals for approximately 3.5 h (100 mg/kg + 5 maintenance injections of 50 mg/kg at 30 min intervals) produced no alteration in DA turnover for at least 9 h. These results suggest that ketamine anaesthesia will not adversely affect studies investigating central DAergic mechanisms in rats.

3,4-Dihydroxyphenylacetic Acid↗
PubMedDate not supplied

[Changes in hemodynamics and catecholamines during single-level exercise at the anaerobic threshold and 120% of the anaerobic threshold in normal subjects].

Exercise training usually involves the sustained performance of exercise at a prescribed intensity. The effects of exercise performed at the anaerobic threshold (AT) have been widely studied. The effects of single-level exercise on catecholamines and cardiac function were assessed at the AT, and at 120% of the AT in eight healthy Japanese men (mean age 21.9 +/- 1.8 years). 1) Symptom-limited exercise testing utilized the ramp protocol with a bicycle ergometer (20 watts/min) for measuring AT and peak oxygen uptake (peak VO2). 2) Exercise testing was repeated on another day, following the same protocol, with blood sampled to measure norepinephrine (NE) and epinephrine (E) in the resting control state and at the AT and peak exercise. 3) Single-level exercise testing at the AT and at 120% of AT utilized the bicycle ergometer on yet another day. Blood for measurement of NE and E was drawn at 3 and 7 min after achieving a steady-state condition. In addition, the cardiac index (CI) and stroke index (SI) were measured by the CO2 rebreathing method. (1) Mean AT and peak VO2 were 18.3 +/- 1.3 and 40.2 +/- 3.0 ml/min/g, respectively. (2) NE and E measured during ramp exercise testing increased rapidly when the intensity of exercise exceeded the AT. NE measured after 3 and 7 min at the AT during single-level exercise equalled 94.7% and 94.5% of the NE value measured at the AT of ramp exercise, respectively. NE measured after 3 and 7 min at 120% of the AT during single-level exercise was 124.7% and 144.7% at the AT of ramp exercise, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗