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Biomedical subjects

K Onizawa

Publications and source records attributed to K Onizawa.

32 records · Page 2Linked to original sources
PubMed1999

Heme oxygenase-1 expression in oral squamous cell carcinoma as involved in lymph node metastasis.

Thirty-eight oral squamous cell carcinomas (SCCs) were semi-quantitatively analyzed by immunohistochemical staining, and the relation between heme oxygenase-1 (HO-1) expression and the clinical status were correlated. High immunostaining of HO-1 was detected in lymph node metastasis negative groups (P = 0.0018) and in well-differentiated SCCs (P = 0.0016). There were no significant correlations between heme oxygenase-1 expression and other factors, such as size of the tumor, staging, age and sex. These findings further support the proposition that high heme oxygenase-1 expression in oral SCCs can be useful in identifying patients at low risk of lymph node metastasis.

Adult↗
PubMed1999

Usefulness of fluorescence photography for diagnosis of oral cancer.

This study was carried out to evaluate the validity of fluorescence photography as an adjunctive diagnostic method for oral cancer. Fluorescence photography was performed on 130 oral lesions in 130 patients. Lesions showing red, orange or pink fluorescence on the photographs were defined as positive, while all other lesions were considered negative. Seventy-two (91.1%) of 79 carcinomas and 6 (85.7%) of 7 epithelial dysplasias were judged as positive, whereas two (4.5%) of 44 benign lesions that were not dysplasias showed positive fluorescence. Sixty-nine (94.5%) of 73 squamous cell carcinomas showed positive fluorescence. These results suggest that fluorescence photography is useful as an adjunctive diagnostic method for oral squamous cell carcinoma.

Adult↗
PubMed1997

Micro-anatomy of primary lymphatics in oral mucosa: a scanning electron microscopic study.

Primary or initial lymphatics cannot readily be recognised by conventional histological methods because they have usually collapsed in excised tissues. We have investigated the distribution of 81 initial lymphatics in 24 specimens of normal tissue and specimens from 11 squamous cell carcinomas and their relationship with the invasion of carcinoma. We used indirect injection methods and the distended initial lymphatics were observed by scanning electron microscopy. The lymphatics were arranged in a network consisting of integrated lymph capillaries and precollectors in the subepithelial area. There was a zone of high density 100 microm below the epithelium. The arrangement of initial lymphatics in oral mucosa was similar to that in the skin of head, in contrast to initial lymphatics in the skin at other sites. We saw no carcinoma cells penetrating into initial lymphatics and the route of tumourous infiltration into lymphatics deserves further investigation.

Carcinoma, Squamous Cell↗
PubMed1996

Fluorescence photography as a diagnostic method for oral cancer.

This study was carried out to evaluate the diagnostic utility of autofluorescence photography for oral mucosal lesions. The materials consisted of 15 chemically-induced lesions containing carcinomas in 15 hamsters, and 32 oral lesions in 30 patients. In the animal models, orange fluorescence was detected in all squamous cell carcinomas invading the muscle layer, and the intensity of the fluorescence increased with the progress of the lesions. In the clinical application, orange fluorescence was detected in 14 of 16 malignant tumors and in one of 16 benign lesions. These results suggest that fluorescence photography may be useful for the diagnosis of oral cancer, particularly for squamous cell carcinoma.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1996

Longitudinal changes of symptoms of temporomandibular disorders in Japanese young adults.

Longitudinal changes of symptoms of temporomandibular disorders in 275 Japanese university students were investigated through use of questionnaires in 1990 and in 1994. A comparison of the 1990 responses with the 1994 responses revealed that the prevalences of temporomandibular joint sounds, mouth opening restriction, and pain significantly increased from 28.7% to 49.8%, from 12.7% to 22.5%, and from 7.6% to 18.5%, respectively. The increase in the prevalence of symptoms mainly resulted for students who did not have symptoms of temporomandibular disorders at the first examination. Subjects who had been frequently aware of symptoms of temporomandibular disorders showed a tendency toward a decrease in their frequency of awareness. Although 66 students (24.0%) reported discomfort from symptoms of temporomandibular disorders during the period, only three (1.1%) visited medical facilities to receive treatment. These results suggest that symptoms of temporomandibular disorders evaluated through the use of questionnaires are longitudinally fluctuant, and that few students developed temporomandibular disorders.

Adult↗
PubMed1995

Alteration of temporomandibular joint symptoms after orthognathic surgery: comparison with healthy volunteers.

PURPOSE: The purpose was to investigate alterations in temporomandibular joint (TMJ) dysfunction after orthognathic surgery. PATIENTS AND METHODS: TMJ symptoms of preoperative patients (n = 30) were compared with those of healthy volunteers (n = 30), and changes in the symptoms were evaluated at 3- and 6-month postoperative intervals. RESULTS: There was no significant difference in the incidence of TMJ sounds, deviation of mouth opening, and tenderness of TMJ and masticatory muscles between patients and volunteers. Patients did not report TMJ symptoms significantly more often than the control subjects. At both 3 and 6 months after surgery, half or more of the patients showed no change in TMJ sounds, deviation of mouth opening, or tenderness of TMJ and masticatory muscles. At each evaluation, some patients exhibited improvement of TMJ symptoms or showed changes for the worse. Findings of TMJ sounds were observed to be associated with the postoperative reduction of mandibular mobility. CONCLUSION: These results suggest that alterations of TMJ symptoms after orthognathic surgery do not always result from the correction of malocclusion.

Adolescent↗
PubMed1993

Dietary diacylglycerol-dependent reduction in serum triacylglycerol concentration in rats.

The effects of dietary diacylglycerol consisting of 1,3 (65.2%) and 1,2 species (32.6%) and triacylglycerol (rapeseed oil) on the serum and hepatic lipid profiles were compared in the rat. The fatty acid composition was similar between these dietary lipids. The dietary acylglycerols were added to the experimental diets so as to provide the same amounts of fatty acids (9.39%). Dietary diacylglycerol compared with triacylglycerol significantly reduced concentrations of serum triacylglycerol at 17 and 34 days of the feeding periods without influencing those of phospholipid and cholesterol. There were no significant differences in the concentrations of hepatic triacylglycerol, cholesterol and phospholipid between the two groups of rats at 34 days of the feeding period. In the second trial, triacylglycerol in the experimental diet was replaced by varying amounts of diacylglycerol while maintaining the fatty acid contents (9.39%). After 14 days of the feeding period, significant reductions in serum triacylglycerol levels were confirmed in the groups of rats fed the diets in which diacylglycerol fatty acids supplied more than 50% (50, 75 and 100%) of total dietary fatty acids. Thus, it was confirmed that dietary diacylglycerol compared with triacylglycerol exerts a potent serum triacylglycerol-lowering effect in the rat.

Animals↗
PubMedDate not supplied

Double-blind controlled study on the effects of dietary diacylglycerol on postprandial serum and chylomicron triacylglycerol responses in healthy humans.

OBJECTIVE: The effects of dietary diacylglycerol (DG) on postprandial lipemia in healthy humans were investigated. METHODS: Forty normolipidemic male volunteers ingested fat emulsions containing either DG oil or triacylglycerol (TG) oil, at different doses: 10 g (n = 13), 20 g (n = 10) and 44 g (n = 17). Two test emulsions were given at seven-days intervals in random order. Fatty acid compositions of the test oils had been adjusted to be equal. Fasting and postprandial serum lipid concentrations in each group and plasma lipoprotein lipids in the 20 g-fat ingestion group were measured during the postprandial intervals. RESULTS: When DG emulsion was ingested, serum TG concentrations were significantly lower (p < 0.05) in the late postprandial phase, i.e., 4 hours, 6 hours as compared to the TG emulsion. The magnitude of postprandial lipemia (the area bounded by the curve above the fasting concentration) after ingestion of 44 g-DG emulsion was significantly less than that of 44 g-TG emulsion (6.54 +/- 5.12 and 8.45 +/- 7.54 mmol x h/L, mean +/- SD, respectively). Chylomicron TG, cholesterol, and phospholipid concentrations at 4 hours after ingestion of DG emulsion were significantly lower (p < 0.05) than those after the ingestion of TG emulsion at the same time point. No marked differences were observed for VLDL, LDL and HDL lipids between the test emulsions. CONCLUSION: In the usual range of fat intake (10-44 g), postprandial response after ingestion of DG emulsion was significantly less than that after ingestion of TG emulsion in healthy human subjects.

Adult↗