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Biomedical subjects

K P Backwinkel

Publications and source records attributed to K P Backwinkel.

At least 19 recordsLinked to original sources
PubMed1984

[2 or 4 daily doses of cimetidine in the treatment of gastric ulcer?].

In a randomized multicentre study of 149 patients with gastric ulcer the effect of 1000 mg cimetidine daily applied in four separate doses was compared to that of 400 mg cimetidine twice a day. In both patient groups similar healing rates were observed. 80.3% and 74.0%, respectively, of the ulcers healed within 6 weeks, and 93.8% and 90.3%, respectively, within 10 weeks. Abdominal pain and antacid consumption decreased under both regimens to a similar degree. Drug safety was good. Lower cost and simplicity in the administration make the b. i. d. regimen of cimetidine preferable to the q. i. d. regimen in the acute treatment of gastric ulcer.

Alcohol Drinking↗
PubMed1978

[Ultrastructural morphometric analysis of normally loaded human myocardial left ventricles from young and old patients (author's transl)].

An ultrastructural and morphometric analysis was performed on human myocardial left ventricle, obtained during surgical heart operations on normally loaded ventricles. The diagnoses of the patients were a) Persistant foramen ovale b) Atrial septal defect stage (I.-II) c) Mitral stenosis (stage III.-IV.). The median values of left ventricular pressure were not pathologically elevated. The patients were divided in 2 groups, the younger one ranging from 5-15 years, the older from 42-78 years. It was shown that the volume density of the interstitial tissue does not differ with the aging process. The number of the nuclei per test area of the heart muscle cells decreased within age (P less than 0.001). This finding suggests a decreasing process in the number of the heart muscle cells and an increase in size of the individual myocardial cell. Increase in the volume density of myofibrils was demonstrated at electron microscopical level with aging (P less than 0.02). The volume density of mitochondria is the same in both groups, whereas the volume density of the remaining cytoplasm (without myofibrils and mitochondria) decreases (P less than 0.05). The numberical density of the mitochondria increased in the older patient group (P less than 0.001).

Adolescent↗
PubMed1976

[Ultrastructure of an atrial myxoma (author's transl)].

Electron microscopic examination of a surgically removed atrial myxoma showed, besides fibrocytes and fibroblasts, mainly isolated smooth muscle cells arranged in solid cellstrands. They are responsible for collagen-and elastin-synthesis. They are presumed to arise from subendocardial smooth muscle cells and considered to be neoplastic.

Adult↗
PubMed1975

[Ultrastructural aspects in the pathogenesis of desoxycholat--pancreatitis (author's transl)].

After intraperitoneal application of desoxycholate in cells of exocrine pancreas, ultrastructural alterations are observed. Initial changes are seen in mitochondria and focal parts of the endoplasmic reticulum. In later experimental stages there is sizable increase in the extent of the initially focal degradations, in such a way that great areas of the cytoplasm are involved. It is remarkable to note, that there are no indications about any disturbance in the synthesis and excretion of zymogen granules. The described morphological alterations will be discussed as conceivably being caused primarily by an irritation in the lipoid metabolism of the membrane.

Animals↗
PubMed1975

[Electron microscopic investigations in the origin of 'ghost bodies' in the aorta].

Electron microscopic studies on aortas of normal mongrel dogs revealed a special form of degeneration of vascular smooth muscle cells and the mode of origin of 'ghost bodies'. These are formed by budding off portions of cytoplasm of smooth muscle cells probably as a result of worsening of the metabolic situation of these cells with increasing age.

Aging↗
PubMed1975

Electron microscopic study on permeability of coronary artery wall of normotensive rabbits using horseradish peroxidase as a tracer.

In order to study the pathways in the coronary artery vessel wall horseradish peroxidase (HRP) was used as a tracer. HRP was injected directly in the left ventricle of rabbit hearts. 30 seconds after intracardial injection of HRP in normotensive rabbits, peroxidase reaction products could be located in random areas of the coronary arterial system and could then be observed in all three layers of the coronary walls at these locations. HRP reaches the subendothelial space of the coronary arteries along two pathways: through intercellular junctions and by plasmalemmal vesicles. Through the fenestations of the internal elastic lamina HRP reaches the media and can be detected between the media smooth muscle cells. The influence of the methodology on the results is discussed.

Animals↗