Transition-metal-mediated dearomatization reactions.
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Journal Article↗
Biomedical subjects
K P Kaliappan
Publications and source records attributed to K P Kaliappan.
Dipolar cycloaddition of rhodium-generated carbonyl ylides with p-quinones.
[reaction: see text] The dipolar cycloaddition of carbonyl ylides generated by the rhodium-catalyzed decomposition of delta- and epsilon-carbonyl-alpha-diazoketones with p-quinones leads to both C=O and C=C addition products. The product ratio is solvent- and catalyst-dependent and has been optimized to favor formation of either product. The C=C addition products of naphthoquinones are used in the assembly of structures hybridizing the illudin and anthraquinone anticancer agents.
Antibiotics, Antineoplastic↗