Hodgkin's disease.
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Antineoplastic Combined Chemotherapy Protocols↗
Biomedical subjects
K P Windebank
Publications and source records attributed to K P Windebank.
ELISA determination of IgG antibodies to pneumococcal capsular polysaccharides in a group of children.
An enzyme-linked immunosorbent assay (ELISA) was developed to measure specific IgG antibody levels to pneumococcal polysaccharide antigens in 300 children attending various hospital departments. By expressing the results as a specific binding index (SBI) of given high and low controls, good reproducibility was obtained. Serum levels of the antibodies were found to fall rapidly during the 1st year of life, plateau during the 2nd and then rise steadily, reaching adult levels by the 7th year.
Antibodies, Bacterial↗
Hydrops fetalis due to abnormal lymphatics.
A case of generalised lymphatic abnormality that presented with hydrops fetalis is described. This seems to be the first such case reported.
Edema↗
Acute lymphoblastic leukaemia presenting with hypercalcaemia.
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Antibodies, Monoclonal↗
Serial study of T lymphocytes in childhood leukemia during remission.
Peripheral blood T lymphocyte numbers and function were studied in 22 children on UKALL X maintenance chemotherapy over a 2-year period, and results were compared with 20 healthy children. CD4 and CD8 subsets were enumerated using indirect immunofluorescence, and specific (HSV-1) and polyclonal (Con A, PWM) activation was studied by proliferation and IL-2/IL-4 production in vitro. T lymphocytes were significantly decreased with a greater fall in CD4 than CD8 T lymphocyte numbers. Proliferation responses were slightly but significantly decreased whereas IL-2 and IL-4 production were not significantly different from control values. These findings suggest that decreased numbers of CD4 helper T cells may be the most important factor in clinical immunodeficiency during maintenance chemotherapy for cALL contributing to increased susceptibility to opportunistic infections and argue against the presence of T lymphocytes with defective function.
Adolescent↗