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K P Zak

Publications and source records attributed to K P Zak.

10 recordsLinked to original sources
PubMed1992

[The effect of insulin therapy on the level of natural killer cells of different immunological phenotypes (CD16+, CD56+ and CD57+) in the blood of patients with diabetes mellitus type I].

Flow cytometry with monoclonal antibody Leu-7 (CD57), Leu-11 (CD56) and Leu-19 (CD56) were used to study the content of different subpopulations of natural killer cells (NK-cells) in the blood of type I diabetes mellitus patients before and after insulin treatment and in healthy people. After a course of insulin therapy most patients showed restoration of the total cell number with antigens on their surface characteristic of NK-cells, especially CD56, that indicates the essential role of hypoinsulin in the depression of the NK-system. At the same time a small group of patients was distinguished who did not show such normalization. This may indicate participation of other mechanisms in the formation of natural immunity failure, in particular, the genetic.

Antigens, CD↗
PubMed1978

[Ultrastructure, metabolism and performance of white blood cells during development of the immune response and the effect of glucocorticoids on it. I. Effect of immunization on the number and submicroscopic structure of lymphocytes and monocytes in the blood of rabbits].

As a result of immunization and reimmunization with bovine serum albumin there was a change of the number and correlation of various morphologically identifyable species of lymphocytes in the blood of rabbits. Regular submicroscopic changes in the nucleus and organoids of the cytoplasm pointing to increased functional activity of these cells were revealed at the ultrastructural level in many circulating lymphocytes belonging to various populations.

Animals↗
PubMed1978

[Ultrastructure, metabolism and function of the white blood cells in the process of the formation of an immune response and in exposure to glucocorticoids. II. The effect of immunization on the number and sub-microscopic structure of granulocytes in rabbits].

The absolute count of different types of granulocytes was determined and their ultrastructure was studied in the blood of rabbits immunized with bovine serum albumin. Both the primary and repeated antigen administration were followed by regular quantitative and qualitative changes in neutrophils, basophils, and eosinophils whose degree and character were determined by the stage of the immune response formation.

Animals↗
PubMed1975

[Submicroscopic formations of an unknown nature in the eosinophils of the blood of dogs].

The authors describe ultrastructure in dog blood eosinophils, unknown formerly. These formations look like dumb-bells or rods, 0,003-0,005 micron in length. A double-contour membrane is distinct under high magnification. The structures contain a homogeneous matrix, more electron-dense than the matrix of the cytoplasm itself. They are distributed mostly in groups (3-4), in parallel, at a small distance from one another; sometimes they are scattered singly at the periphery of the cytoplasm. Several suggestions were made on the role of the mentioned structures in the eosinophilic leukocyte function.

Animals↗
PubMed1975

[Effect of the multiple administration of hydrocortisone on the ultrastructure of the lymph nodes of rabbits].

The effect of dayly multiple exposure to hydrocortison in the dose 1 mg/kg on the submicroscopic structure of the mesenteric lymphatic nodes in rabbits was studied. In contrast to a single-dose administration of the hormone, no pycnotic forms of small and middle lymphocytes were observed. Prolonged application of hydrocortison led to the appearance of atypical forms of reticular cells, an increase in the number of plasmatised lymphocytes, as well as of mature plasmatic cells. Macrophages disappear almost entirely. The number of dark lymphocytes and reticular cells with the thickened matrix of the cytoplasma and great number of ribosomes and polysomes increased considerably. Mechanisms of action of single and multiple doses of hydrocortison on the cells of lymphatic nodes was not identical.

Animals↗