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Biomedical subjects

K Pandya

Publications and source records attributed to K Pandya.

24 records · Page 2Linked to original sources

Hypothyroidism and ventilator dependency.

Four patients with long-term ventilator dependency and severe hypothyroidism discovered in a single year are described. Correction of hypothyroidism was helpful in weaning three patients from the ventilator. The fourth patient died of other medical problems. None of these patients had goiter or clinical evidence of hypothyroidism. Hypothyroidism was discovered during workup for neurologic or cardiologic problems. Although hypothyroidism is not a common cause of ventilator dependency, it might be more common than we think.

Aged↗

Tissue sensitivity to acetylcholine, adrenaline, noradrenaline and serotonin and agents acting on sulphydryl groups.

Parachloromercury benzoate (PCMB), a sulphydryl inactivator, caused a progressively increasing inhibition of tissue responses to acetylcholine, adrenaline, noradrenaline and serotonin in vitro. This inhibition was progressively and completely reversed by penicillamine, a sulphydryl activator. It is inferred that intact sulphydryl groups are essential for constancy of responses of excitable tissues to the neurotransmitters.

Acetylcholine↗