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Biomedical subjects

K Papadimitriou

Publications and source records attributed to K Papadimitriou.

30 records · Page 2Linked to original sources
PubMed1976

Long-term results from use of fascia lata as arterial graft.

Of twenty-four dogs, fifteen survived up to two years after aortic replacement with fresh fascial graft. Surviving dogs underwent hemodynamic study and cineaortography. Histology of the graft was examined after the dogs were sacrificed. Length of the graft used is an important factor for both dog survival and graft hemodynamics. The shorter the aortic segment replaced the better the chances for long-term graft patency.

Animals↗
PubMed1976

[A chordoma of sacrococcygeal region as a cause of nephrotic syndrome (author's transl)].

A case of nephrotic syndrome connected with a chordoma of the sacrococcygeal region in a man aged 27 is described. Biopsy of the kidney revealed a diffuse membranous glomerulonephritis. Immunofluoresecenc showed deposits of IgG immunoglobulin on the basal membrane of glomeruli. In the patient's serum autoantibodies against chordoma cells were found. Those were also IgG globulins. To our knowledge such a relation of chordoma and nephrotic syndrome has not been described yet.

Adult↗
PubMedDate not supplied

[Our experience with functional ascending cinephlebography].

Over the last three years, ascending, functional cine-phlebography has been used on 43 patients with different lesions of the venous system. The patient is placed in the decubitus dorsal position, on a radiological table inclined at 70 degrees. The opaque liquid is injected into the dorsal vein of the foot. Its movement is helped by the flexing of the muscles of the leg, and is followed on a screen. This method makes it possible to follow the morphological and functional aspects of the veins of the lower limbs. In this way it is possible to assess valvular function, the location of the perforating veins and their competence, the limits of a thrombosis, and the therapeutic results. This examination, which is painless and harmless, makes it possible to improve the precision of the diagnosis in patients with different vein lesions, and gives most valuable information on the functioning of the venous system of the lower limbs.

Cineangiography↗
PubMedDate not supplied

C-erbB-2 expression in squamous cell carcinoma of the head and neck.

Seventy-five squamous cell carcinomas of the head and neck were analysed for c-erbB-2 expression using immunohistochemical techniques with four different c-erbB-2 antibodies. No membrane staining was seen in any of the squamous cell carcinomas studied with any of the antibodies; however, c-erbB-2 cytoplasmic staining was seen in 60 per cent of the tumours. The significance of cytoplasmic staining is discussed and that it may possibly represent elevated c-erbB-2 expression in squamous cell carcinomas. C-erbB-2 cytoplasmic staining was also observed in 10 of 23 normal specimens obtained from the resection margin of the tumours. No correlations were found between positive c-erbB-2 cytoplasmic staining and any of the clinicopathological parameters or survival.

Biomarkers, Tumor↗
PubMedDate not supplied

Evaluation of the ras and myc oncoproteins in benign gastric lesions.

Ras and c-myc oncoprotein expression was analyzed using specific monoclonal antibodies Y13-259 (for ras p21) and mycl-9E10 (for c-myc p62) in 144 histological sections derived from benign gastric lesions. Increased expression of ras p21 was observed in inflammatory metaplastic, dysplastic, hyperplastic and cystic histological changes, and on the basis of ras p21 staining three distinct histological groups emerged: (i) cystic changes, hyperplastic polyps; (ii) inflammatory gastritis; (iii) metaplastic, dysplastic and adenomatous polyps. Elevated levels of ras p21 expression were found at significantly higher levels than those of c-myc expression in dysplastic lesions. However the expression of the c-myc oncoprotein was less frequent than ras p21 in all other histological types. With the exception of parietal cells, normal stomach mucosa was found to express low levels of both ras p21 and c-myc oncoproteins.

Antibodies, Monoclonal↗
PubMedDate not supplied

ras, c-myc and c-erbB-2 oncoproteins in human breast cancer.

The expression of ras, c-myc and c-erbB-2 oncoproteins in 100 human (73 ductal and 27 lobular) breast carcinomas has been examined using an immunohistochemical analysis. The monoclonal antibody Y13 259 has been used for the ras p21, the monoclonal antibody Myc1-9E10 for the c-myc p62 and the polyclonal antibody pAb1 (from Triton Bioscience Inc.) for the c-erbB-2 p185 oncoproteins. The following conclusions can be drawn from the analysis: Of the 100 breast carcinoma cases studied only 14 did not express any of the three oncogenes. The remaining 86 were positive for one or more of the three oncoproteins. Ductal carcinomas expressed oncoproteins in 92% of the cases (67/73), whereas lobular carcinomas expressed them in 70% of the cases (19/27). The most frequently expressed was c-myc p62 in 70% of cases followed by ras p21, 55% and c-erbB-2, 35%. Elevated expression of ras, myc or erbB-2 oncogenes did not correlate with the presence of metastasis in auxiliary lymph nodes, the numbers of infiltrated lymph nodes the grade of the tumor or hormone status. However, there appears to be a correlation between increased ras staining intensity and patient's age, below 50 years.

Adult↗
PubMedDate not supplied

Expression of the ras oncoprotein in gastric carcinomas and adjacent mucosa.

We have employed an immunohistochemical analysis to study the ras p21 oncoprotein in a total of 88 gastric carcinomas, which were associated (in 24 cases) with intestinal metaplasia. Our results suggest an association of the expression of ras p21 with metaplastic and neoplastic gastric mucosa. The comparative study showed that 58 of the 88 gastric carcinoma cases studied exhibited negative or equivocal staining (-/+). The remaining 30 were positive with moderate (+) or intense (++) staining. There was an agreement in that histologic type and tumor grade had a strict correlation with staining intensity. Intestinal metaplasia had a higher percentage of positively stained cells (+ or ++). Moreover, there was a selective positive staining in the parietal cells of the gastric fundus in sections from adjacent non-neoplastic mucosa.

Adenocarcinoma↗
PubMedDate not supplied

Immunohistochemical analysis of the ras oncogene protein product in human thyroid neoplasms.

The monoclonal antibody Y13 259 to the ras oncogene p21 product was used in an immunohistochemical study of ras expression in human thyroid neoplasms. Both papillary and follicular carcinomas showed consistently higher staining intensity than normal tissue adjacent to carcinomas. Some follicular, foetal, embryonal and oxyphil adenomas exhibited higher staining intensity than normal tissue. Our results suggest that elevated ras expression may be important in the development of some adenomas and in their conversion to carcinomas.

Adenocarcinoma↗