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Biomedical subjects

K Pape

Publications and source records attributed to K Pape.

14 recordsLinked to original sources

[Minimizing of local anesthetic dose in dental surgical treatments].

It is possible to operate painless in outpatients with for smaller local anesthetic doses as till now usually. Clinical examinations showed that 1-1.5 ml of the 2% Xylocitin Solution with 0.001% epinephrine are enough. The increase of the local anesthetic dose causes no anesthetic intensification but a prolongation of the anesthesia. Further is the avoidance of the stress situations for the patient by a accentuated psychical management necessary.

Anesthesia, Dental

[Tumors of the peripheral nervous system in the region of jaw and face].

Benign and malign forms of tumors of the peripheral nervous system also occur in the region of jaw and face. They demonstrate a quite different dignity and different courses. Very well known is the neurofibromatosis (Recklinghausen) which can be observed in several variants in face. The possibility is pointed out that primarily benign tumours of the peripheral nervous system may be degenerated to malign ones and the course as well as the therapy with benign and malign tumours are being described.

Adult

[Osteitis deformans].

Osteitis deformans is a bone disease of still unknown aetiology which shows characteristic symptoms in the maxillofacial region. An increase in size of the entire calvarium and also of single bones of the facial skeleton belongs to these symptoms. A triad may be seen in the jawbone: osteoporosis, foci of densification and cementum hyperplasia. No possibility of treatment was known in the past. Nowadays, the use of cytostatics, calcitonin and diphosphonates seems to be promising.

Alkaline Phosphatase

Oral cimetidine in reflux esophagitis: a double blind controlled trial.

The efficacy of cimetidine (1.6 g per day) was evaluated using a double blind placebo-controlled trial in 24 patients with moderate or severe peptic reflux esophagitis. The results show that cimetidine is superior to placebo when using endoscopic and histological criteria. Improved patient symptomatology and lower antacid comsumption failed to reach statistical significance. No change in the abnormally low lower esophageal sphincter pressure was observed at the end of the trial. No clinical side effects or significant biochemical changes were noted during the trial.

Administration, Oral

[Hyperparathyroidism].

The overproduction of parathyroid hormone as caused by a simple hyperplasia or an adenoma leads to pathological changes in various organs which are termed primary hyperparathyroidism. The blood phosphates increase in case of long-standing disturbances of the metabolism, e.g. chronic renal insufficiency. In this way and due to other causes, the production of parathyroid hormone is increased. The resultant clinical picture is termed secondary hyperparathyroidism. Both forms are associated with osseous changes also in the maxillofacial skeleton. Tertiary hyperparathyroidism may develop from secondary hyperparathyroidism if the metabolic disorder in the renal form cannot be eliminated by kidney transplantation and if the process in the parathyroid becomes independent (autonomous hyperparathyroidism). Besides these three forms, there are two others, quaternary hyperparathyroidism and quinary hyperparathyroidism, which are described.

Bone Diseases

[Fibrous dysplasia].

Fibrous dysplasia of bone may occur also in the facial skeleton. Main locations are the lateral midface and the mandible. The foci, which are sharply circumscribed in most cases, produce tumour-simulating deformities of single of several facial bones and, in part, disorders of the articulation are bulbar displacements. In contrast to Paget's disease, fibrous dysplasia is a disorder of the younger age groups. Apart from bony changes, Albright's syndrome (which occurs in women only) comprises also irregular, circumscribed café-au-lait patches and signs of somatic and sexual precocity.

Facial Bones