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Biomedical subjects

K Patterson

Publications and source records attributed to K Patterson.

At least 145 records · Page 8Linked to original sources
PubMed1985

Treatment of word retrieval deficits in aphasia. A comparison of two therapy methods.

The effects of two therapy methods in the treatment of picture naming problems are compared, using a within-patient design with 12 adult patients with chronic acquired aphasia. We contrast techniques that require the patient to process the meaning corresponding to the picture name (semantic treatment) with those that provide the patients with information about the phonological form of the name (phonological treatment). With each method, patients either had 4 sessions of treatment over one week, or 8 sessions over two weeks. Both methods caused day-by-day improvement that was specific to the actual items treated. Both methods resulted in significant improvement in naming when this was measured one week after the end of treatment, with a small, but significant advantage for the semantic treatment; this is mainly due to improvement that generalizes to untreated items. We conclude that specific and theoretically motivated treatment methods can cause significant improvement in the word retrieval ability of patients with chronic aphasia.

Adult↗
PubMed1984

Benign hepatocellular tumors in the young. A clinicopathologic spectrum.

Hepatic tumors unassociated with cirrhosis were encountered in seven patients aged 10 to 19 years. Four patients had received androgens for aplastic anemia. Two patients had transfusional hemosiderosis. One patient had had a renal transplant 2 1/2 years ago. Two patients are alive at 2 3/4 and 2 1/2 years after surgical resections. Nodules were found at autopsy in the others. The tumors were well differentiated and, in the androgen-related cases, differed from the others in the following features: canalicular bile retention, mild nuclear atypia, and acinar formation. No mitoses, vascular invasion, or metastatic tumor were evident. The clinical setting was variable; different factors, including iron overload and androgen therapy, played a role in the development of tumor. Although the androgen-related cases showed mild cellular atypia, biologic evidence of malignancy was lacking as in most previous reports.

Adolescent↗
PubMed1983

Effects of grinding and storage for one month on retention of vitamin A in premixes and mineral supplements.

Tested standardized procedures for handling premixes and mineral supplements from time of sampling to time of analysis for vitamin A have not been developed, which could account for some unexplained inconsistent and low analytical results. Grinding premix samples and storing them in a freezer for one month had little effect on amount of vitamin A found, but there was a significant loss (about 10%) after storage for one month at room temperature. Results on replicated determinations of vitamin A in unground and ground mineral supplements and on effect of storage were somewhat more variable than for premixes, but only the loss (about 12%) during storage for one month at room temperature was significant.

Animal Feed↗
PubMed1981

Terminal deoxynucleotidyl transferase expression in acute non-lymphoid leukaemia: an analysis by immunofluorescence.

Indirect immunofluorescence for terminal transferase enzyme (TdT) was used to study the blasts of 64 patients with acute non-lymphoid leukaemia (ANLL). In 32 patients no TdT positive cells were seen. In 19 cases a small subpopulation of cells expressing TdT was detected; these constituted up to 5% of total nucleated cells, and it was not clear whether these TdT positive cells were part of the leukaemic process or represented residual normal bone marrow lymphoid cells. The remaining 13 patients had TdT positive cells accounting for 7-90% of the total. In two of these cases TdT was expressed on blasts with myeloid features, representing an aberrant expression of TdT by myeloid cells; in contrast, in three cases mixed populations of TdT positive lymphoid blasts and TdT negative myeloid blasts were observed. In the remaining cases it was not possible to determine whether the TdT positive cells had definite lymphoid or myeloid features. Cytogenetic analysis showed no evidence of the Philadelphia chromosome. Response to treatment was assessed in 11 of the 13 patients. Only one patient remitted with the initial choice of therapy (DAT); four failed to respond to initial regimes of vincristine and prednisone (V & P) while the other five patients did not respond to myelotoxic combinations (DAT). Only one patient subsequently entered complete remission on second line therapy (V & P). This group of patients with TdT+ ANLL had a particularly bad prognosis, and appeared to differ from cases of TdT positive acute undifferentiated leukaemia, which often respond to V & P therapy.

Acute Disease↗
PubMed1980

The histones of yeast. The isolation and partial structure of the core histones.

The four core histones of yeast chromatin have been isolated. Amino acid composition, electrophoretic mobility and partial sequences identify one variant each of the histones H3 and H4, whereas the histones H2A and H2B are represented by two variants each. In the yeast histones H3 and H4 7% of the residues, positioned in the partial sequences vary if compared with the corresponding histones from higher plants and animals, for the histones H2A and H2B from yeast this figure is 20%.

Amino Acid Sequence↗
PubMed1975

Behavior modification consultation in a Mexican-American school: a case study.

Following consultation by two psychologists with an elementary school populated primarily by Mexican-American students, absenteeism was chosen as the first problem area to attempt to change. A between-groups experimental design was used to evaluate the effect of contigent rewards on the students' attendance. Analysis of the data showed no improvement in attendance. The results of the study were discussed in terms of (1) a more thorough behavior analysis of the absenteeism problem, (2) methodological restraints of a between-groups experimental design, (3) the need for consultants to be familiar with the community in which they work, and (4) relatedly, the success of the local school psychologist in implementing behavior modification programs.

Behavior Therapy↗
PubMed1975

Differential hemispheric mediation of nonverbal visual stimuli.

Studies employing schematic faces of three features explored the role of the left hemisphere as an analytic processor in difficult discriminations and the role of the right hemisphere in easy gestalt matches. In a discrimination task, the successively presented members of a stimulus pair differed in all three features. When both stimuli went to the same visual field there was a Visual Field X Judgments interaction; judgments same were processed faster in the left visual field. When a test stimulus differing on all three features from a previously memorized target face was matched to the latter, both judgments same and different were made faster for stimuli in the left visual field. However, when the test stimulus and the memory items differed on only one feature the right field proved superior for both judgments same and different.

Adolescent↗