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Biomedical subjects

K Pavri

Publications and source records attributed to K Pavri.

11 recordsLinked to original sources
PubMed1986

Neutralizing antibody response to Japanese encephalitis inactivated mouse brain vaccine among laboratory personnel.

Among vaccinees given two doses of JE Nakayama strain liquid vaccine, 41.8% had significant neutralizing (N) antibody response to the P20778 strain and 48.6% to the Japanese Nakayama strain. Among vaccinees who received three doses of the freeze-dried vaccine, the proportion of positive reactors was 53.8% when the sera were tested with the P20778 strain and 47.4% with the Nakayama strain. A fairly large proportion of those vaccinees who had responded positively to the latter vaccine were found to have lost detectable N antibodies to the P20778 strain and a smaller proportion to the Nakayama strain 13 to 17 months after the third dose of vaccine. Following the administration of a booster dose of the vaccine after this time interval, 65.2% and 56.5% of vaccinees responded positively to the P20778 strain and the Nakayama strain, respectively. The differences between the proportion of positive reactors to the two strains were not significant either for the liquid vaccine or the freeze-dried vaccine. An important finding was the priming effect of infection with West Nile (WN) virus before vaccination. Those vaccinees who had N antibody to WN virus before vaccination had a significantly higher N antibody response to the P20778 strain of JE virus than those who had no detectable antibody to WN virus. These findings indicate that the JE Nakayama strain vaccine would be efficacious in India, particularly in view of the widespread prevalence of WN virus infection.

Antibodies, Viral↗
PubMed1986

Single-radial-haemolysis test for diagnosing flavivirus infections, particularly Japanese encephalitis.

Use of the single-radial-haemolysis (SRH) technique for the diagnosis of flavivirus infections is described. A large number of paired and single convalescent serum samples collected from cases of encephalitis during two major outbreaks in Kolar district of Karnataka State in India during 1977 and 1979 were tested by this technique. The results were compared with those obtained in the haemagglutination inhibition (HI) test in all cases, and the complement fixation (CF) and neutralization tests in some cases. Japanese encephalitis virus was shown by the SRH test to be the major etiologic agent responsible for both epidemics. This was corroborated by the HI, CF and neutralization test results. The single-radial-haemolysis test was found to be simpler and more specific and sensitive than the haemagglutination inhibition test.

Encephalitis, Japanese↗
PubMedDate not supplied

Clinical, clinicopathologic, and hematologic features of Kyasanur Forest disease.

In 1957, a fatal disease occurred among monkeys in a forested area of Shimoga District, Karnataka State, India. Concurrently, there was an outbreak of febrile, occasionally fatal illness among people living in the vicinity. The disease was caused by a new tick-borne flavivirus belonging to the Russian spring-summer encephalitis complex of viruses. The early clinical description of the disease included severe cases with hemorrhagic manifestations, including intermittent epistaxis, hematemesis, melena, and frank blood in the stools. Pathologic and hematologic investigations emphasized similarities with Omsk hemorrhagic fever. Two years later there was a shift in clinical emphasis from hemorrhagic to neurologic complications; this could have resulted from the special interests or bias of the principal investigator or the changing patterns of intercurrent infections. Clinical, clinicopathologic, hematologic, and hemostatic features of Kyasanur Forest disease (KFD) are described, particularly in relation to IgE as a cofactor in the immunopathology of KFD and possibly of other hemorrhagic fevers.

Animals↗