Biomedical subjects
Publications and source records attributed to K Peacock.
A positive life-changing experience of joint replacement surgery from the point of view of a patient with Factor VII inhibitor.
While it is frequently advantageous to be able to use our hands independently, many actions demand that we use our hands co-operatively. In this paper we present two experiments that examine functional binding between the limbs during the execution of bimanual reach-to-grasp movements. The first experiment examines the effect of gaze direction on unimanual and bimanual reaches. Even when subjects' eye movements are restricted during bimanual reaches so that they may only foveate one target object, the limbs remain tightly synchronized to a common movement duration. In contrast, grip aperture is independently scaled to the size of the target for each hand. The second experiment demonstrates however, that the independent scaling of grip aperture is task dependent. If the two target objects are unified so that they appear to be part of a single object, grip apertures become more similar across the hands (i.e., grip aperture to the large target object is reduced in size while peak aperture to the small target item is increased in size). These results suggest that the coupling of the limbs can operate at a functional level.
Function was evaluated in a 12-year-old girl who had traumatic, bilateral proximal humeral amputation at seven years of age. Unilateral successful replantation was performed with subsequent nerve grafts and tendon transfers to improve function. The contralateral side was fitted early after amputation with a body-powered prosthesis. Subjectively, the patient preferred the replanted side for activities of daily living. The range of motion and strength was better overall on the replanted side. Sensory return, although poor when compared with a normal hand, allowed the patient when blindfolded to identify objects placed in the hand. The replanted arm offers better function than the prosthesis for most activities.
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Fifty-three hypertensive patients from one practice, of whom forty-two were new patients, were treated with Prestim--a fixed dose combination of 10 mg timolol maleate and 2.5 mg bendrofluazide. After a 2-week placebo run-in period, dose titration took place at weekly intervals up to a maximum of 4 tablets daily. Stabilized patients were followed-up at 3 months and approximately 1 year. At the 3-month follow-up, forty-nine patients were evaluated. Forty-two patients (85%) were well controlled (diastolic blood pressure below 95 mm Hg) on Prestim at a mean daily dose of 1.4 tablets. Four patients stopped therapy due to side-effects and in three patients the blood pressure was uncontrolled on the maximum dose of 4 tablets daily. After 1 year, thirty-four patients (75%) were still well controlled on a mean dose of 1.3 tablets daily. A further two patients were lost to follow-up and six other patients stopped therapy during the last nine months of the study. There were no unexpected side-effects and the general biochemical profile remained unaltered.