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Biomedical subjects

K Pietrzak

Publications and source records attributed to K Pietrzak.

10 recordsLinked to original sources
PubMed2000

Pregnancy outcome following gestational exposure to echinacea: a prospective controlled study.

BACKGROUND: Echinacea products are among the most popular phytomedicines on the North American market. Since at least half of all pregnancies are unplanned, many women inadvertently use echinacea in their first trimester. Presently, there is a paucity of information regarding the gestational safety of this herb. The primary objective of this study was to evaluate the safety of echinacea in pregnancy when used for upper respiratory tract ailments. PATIENTS AND METHODS: The study group consisted of women who were prospectively followed up after contacting the Motherisk Program regarding the gestational use of echinacea. This cohort was disease-matched to women exposed to nonteratogenic agents by maternal age, alcohol, and cigarette use. Rates of major and minor malformations between the groups were compared. RESULTS: A total of 206 women were enrolled in the study group after using echinacea products during pregnancy; 112 women used the herb in the first trimester. There were a total of 195 live births, including 3 sets of twins, 13 spontaneous abortions, and 1 therapeutic abortion. Six major malformations were reported, including 1 chromosomal abnormality, and 4 of these malformations occurred with echinacea exposure in the first trimester. In the control group, there were 206 women with 198 live births, 7 spontaneous abortions, and 1 therapeutic abortion. Seven major malformations were reported. There were no statistical differences between the study and control groups for any of the end points analyzed. CONCLUSIONS: This first prospective study suggests that gestational use of echinacea during organogenesis is not associated with an increased risk for major malformations.

Congenital Abnormalities↗
PubMed1999

[Clinical usefulness of color doppler flow examination during treatment of gestational trophoblastic disease].

Neovascularisation is the integral part of tumor development. Presence and type of pathological vascularisation can be used in therapy monitoring and follow up. The value of beta HCG and pulsatility index (PI) and resistance index (RI) in 14 women treated for nonmetastatic persistent trophoblastic disease (NMTD) were been compared. There was statistical, significant correlation between dropped BHCG level and increased value of RI. No correlation between BHCG blood concentration and values of PI was observed. In summary it should be stated that color Doppler ultrasonography is useful method in monitoring patients with NMTD.

Adult↗
PubMed1998

DNA ploidy as a prognostic factor in patients with ovarian carcinoma.

The aim of this work was to establish the dependence between survival and time to progression and the factor which is considered as risk factor i.e. type of DNA ploidy. The DNA ploidy was evaluated in 33 cases of ovary carcinoma selected from 314 cases. The statistically significant difference between the 5 years survivals in patients with DNA aneuploidy and patients with DNA diploidy was observed (13.6% vs 60.9%). What was also found out, was the statistically significant difference between the 5 years survivals without the progression of disease in patients with DNA aneuploidy and patients with DNA diploidy (13.6% vs 55.9%).

Animals↗
PubMed1995

Is laparotomy for staging early ovarian cancer an absolute necessity?

STUDY OBJECTIVE: To demonstrate that palpation of the omentum, mesentery, and intestine can be omitted from the laparoscopic staging of stage I carcinoma of the ovary. DESIGN: Retrospective analysis of 223 women with stages III and IV ovarian cancer treated by laparotomy. SETTING: Gynecological Oncology Clinic, M. Sklodowska-Curie Memorial Cancer Institute of Oncology, Warsaw, Poland. INTERVENTIONS: Observation of macroscopic spread of tumor to areas accessible to laparoscopic inspection versus spread to areas inaccessible to laparoscopic evaluation. MEASUREMENTS AND MAIN RESULTS: Macroscopically detectable disease in the areas easily accessible to laparoscopic inspection was present in all cases of metastases to the mesentery, omentum, or intestine. CONCLUSION: The diagnosis of FIGO stage I ovarian cancer can be made with confidence if laparoscopic inspection of certain areas reveals no evidence of metastases.

Adnexa Uteri↗
PubMed1993

Clinical analysis and evaluation of the results of adjuvant treatment (radiotherapy and chemotherapy) in ovarian carcinoma.

The present study was carried out on the material of 486 ovarian cancer patients who received radiotherapy and chemotherapy as adjuvant treatment at the Oncological Gynaecology Clinic at the Maria Skłodowska-Curie Cancer Center-Institute of Oncology in Warsaw in the period 1979-1985, following primary surgery. The clinical stage of disease advancement was determined on the basis of surgery protocols and histological examinations. Radiotherapy was the treatment of choice in patients in stages I and II. Irradiation was applied to the pelvis minor and para aortal nodes (in patients at stage Ia) or to fields covering the entire abdominal cavity (other patients at stage I and II). Chemotherapy was given to stage III and IV patients multi-drug therapy, usually including Cisplatin, Adriamycin, and Cyclophosphamide, or with one drug (monochemotherapy) with the alhylating agents. The largest group of patients under study were women with ovarian cancer in stage I (38.8%), the smallest group consisted of patients in stage IV (8.5%). Patients in stage III represented 37.5% of all the material. Patients aged 50-64 years were most frequently treated (47.3%), the least frequent group were the patients aged over 65 (13.2%). The predominating histological diagnosis was serous cancer type (48.7%), clear-cell cancer was detected least frequently (13.2%). Among all the patients treated 35.4% survived 5 years after treatment, 69% in stage I, 43.8% in stage II, 8.8% in stage III, and 2.5% in stage IV.

Adult↗
PubMed1993

The management of granulosa-cell tumors of the ovary based on long-term follow up.

The results of treatment in 130 cases of GCT of the ovary treated in the Institute of Oncology in Warsaw and followed up from 5 to 40 years were analysed with respect to the methods of therapy and age of the patients. The highest 5-year survival rate (86%) was obtained by combination of radical surgery with external irradiation. Such treatment also resulted in the lowest percentage of early and late failures of the treatment (17%). Conservative surgery, applied in the Ist stage of GCT resulted in 69% of 5-year survivals and gave young women a chance of procreation; however, the majority (69%) of patients who underwent this treatment sooner or later developed a recurrence leading, in consequence, to death.

Adolescent↗