Biomedical subjects
Publications and source records attributed to K Pradhan.
We report an unusual case of primary intracranial germinoma involving the sphenoid bone and sinus. To the best of our knowledge, paranasal sinus and bone invasion of primary intracranial germinoma has not been previously reported. Recognition of this rare form of presentation by imaging is important because early radiation and chemotherapy can result in a cure of this neoplasm.
Adult male fistulated crossbred cattle and buffalo, four each, were on rations with rations of nonprotein nitrogen to carbohydrates of 1:45, 1:37.5, and 1:30 and a control of no urea in a 4 x 4 Latin square switchover design. The influence of various test diets on enzymes assimilating ruminal ammonia was elucidated to find an optimum ratio of nonprotein nitrogen to soluble carbohydrates for efficient utilization of dietary nitrogen. Inclusion of urea in graded amounts in the ration induced activities of amino-stransferases. Specific activities of trans-aminases were higher in cattle and buffalo for rations with ratios of 1:45 and 1:30 compared to control and 1:37.5 (nonprotein nitrogen to carbohydrate ratio). This indicates a better adaptation of rumen microbes on two former rations which did not differ in augmentation of enzyme activities. Peak enzyme activity of cattle and buffalo at 2 h postfeeding did not differ for microbial enzymes. The ration with narrowest nonprotein nitrogen and carbohydrate ratio (1:30) may be optimum for microbial synthesis of amino acid. It will be worthwhile to study whether a still narrower ratio can make feeding of ruminants more economical.
Two each adult male crossbred cattle and murrah buffalo were fed a diet of alfalfa hay, chopped wheat straw, and concentrate mixture. Total rumen transaminase activity of cattle was higher than that of buffalo. Rumen protozoal fractions showed higher total transaminase activity than bacterial fractions in both ruminant species. Besides generally studied glutamate oxalacetate transaminase and glutamate pyruvate transaminase, a large number of other microbial transaminases also have been detected in the rumen of both the ruminant species. Bacterial fractions of rumen liquor were devoid of transaminases utilizing tryptophan, threonine, and lysine as their substrates. Ruminal ammonia and nonprotein nitrogen were correlated positively with microbial transaminases in both species. Transamination reactions may be important for assimilation of ruminal ammonia to cellular proteins.
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The inhibitory effect of the protease inhibitor aprotinin (Trasylol) on the invasion of mouse kidney explants by polyoma virus transformed BHK21 cells was investigated using a mixed cell/organ culture technique. The extent of invasion was monitored by following the changes in LDH isoenzyme pattern in the explants and by histological assessment. The kidney explants containing aprotinin were found to maintain a normal kidney LDH pattern and to suffer considerably less invasion than the explants not containing the drug. These results support the idea that proteolytic enzymes are associated with invasion and that inhibitors of protease activity could possibly be useful in the management of clinical cancer.
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