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Biomedical subjects

K Puro

Publications and source records attributed to K Puro.

16 recordsLinked to original sources
PubMed1986

Glycoproteins of human teratocarcinoma cells (PA1) carry both anomers of O-glycosyl-linked D-galactopyranosyl-(1----3)-2-acetamido- 2-deoxy-alpha-D-galactopyranosyl group.

Two disaccharide alcohols, alpha-D-Galp(1----3)-GalNAcol and beta-D-Galp-(1----3)-GalNAcol, together with a GalNAcol-containing tetra- or penta-saccharide alcohol, were released from human embryonal carcinoma cells of line PA1 by reductive beta-elimination. The disaccharides were identified by exoglycosidase digestions and by periodate oxidation. The results were confirmed by affinity chromatography of the disaccharide alcohols on immobilized Bandeirea simplicifolia lectin and by chromatography of the parent glycopeptides on immobilized peanut lectin.

Carbohydrate Conformation↗
PubMed1976

Ganglioside pattern and neuraminic acid content of human gastric and colonic carcinoma.

Twenty-five human gastric and 11 human colonic adenocarcinomas were analysed for their ganglioside pattern and for their content of lipid-bound and protein-bound neuraminic acid. In most carcinomas the content of both lipid-bound and protein-bound neuraminic acid was increased by an average of four- and two-fold, respectively. The ganglioside pattern of all the carcinomas resembled that of normal tissue. In six gastric carcinomas the content of lipid-bound neuraminic acid and the ratio of lipid-bound neuraminic acid to protein-bound neuraminic acid (L/P ratio) were lower than those of normal gastric mucosa. These carcinomas were significantly larger than the rest of the tumours.

Adenocarcinoma↗