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Biomedical subjects

K R Brody

Publications and source records attributed to K R Brody.

11 recordsLinked to original sources
PubMed1978

Iodine heterocycles: [125I] and [131I] ortho-iodosophenylphosphoric acid.

Since organic molecules tagged with radioiodine are often subject to dehalogenation, techniques are needed for "protecting" the iodine. A suggested approach was the incorporation of iodine directly into a heterocyclic compound as one of the ring's heteroatoms. Such a compound, orthoiodosophenylphosphoric acid, was synthesized with I-125 and I-131. Upon i.v. administration to dogs and rabbits, most of the radiolabel was excreted in the urine. There was no evidence of the appearance of free iodide. The renal elimination of orthoiodosophenylphosphoric acid was contrasted with the biliary excretion of another iodine heterocycle, diphenyleneiodonium. Iodine heterocycles, with appropriate substituents, may represent a useful class of compounds for biologic studies.

Animals↗
PubMed1976

Technetium-99m labelled imidodiphosphate: an improved bone-scanning radiopharmaceutical.

Technetium-99m labelled imidodiphosphate was prepared in the presence of stannous ions. It was evaluated as a bone-scanning agent in animals and patients. Comparative tissue distribution studies in mice showed a relatively higher uptake of radioactivity in bone when 99Tcm -labelled pyrophosphate and diphosphonate. Accumulation of radioactivity in soft tissues, especially kidneys, was less with this radiopharmaceutical. Results in patients were most satisfactory in delineating skeletal bone and identifying bone lesions with relatively small tracer doses of the radiopharmaceutical.

Animals↗