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K R Fowler

Publications and source records attributed to K R Fowler.

2 recordsLinked to original sources

Application of heuristic optimization techniques and algorithm tuning to multilayered sorptive barrier design.

Although heuristic optimization techniques are increasingly applied in environmental engineering applications, algorithm selection and configuration are often approached in an ad hoc fashion. In this study, the design of a multilayer sorptive barrier system served as a benchmark problem for evaluating several algorithm-tuning procedures, as applied to three global optimization techniques (genetic algorithms, simulated annealing, and particle swarm optimization). Each design problem was configured as a combinatorial optimization in which sorptive materials were selected for inclusion in a landfill liner to minimize the transport of three common organic contaminants. Relative to multilayer sorptive barrier design, study results indicate (i) the binary-coded genetic algorithm is highly efficient and requires minimal tuning, (ii) constraint violations must be carefully integrated to avoid poor algorithm convergence, and (iii) search algorithm performance is strongly influenced by the physical-chemical properties of the organic contaminants of concern. More generally, the results suggest that formal algorithm tuning, which has not been widely applied to environmental engineering optimization, can significantly improve algorithm performance and provide insight into the physical processes that control environmental systems.

Algorithms↗

Recovery of function following injections of kainic acid: behavioral, electrophysiological and neuroanatomical correlates.

This research examined the electrophysiological, behavioral and neuroanatomical changes following an injection of kainic acid (KA) which destroyed most of the CA3 pyramidal cells in the hippocampus. For 5 days following the injection of KA, the evoked potential (EP) in the CA1 pyramidal cells produced by stimulation of the perforant path (PP), dentate gyrus (DG), or remaining CA3 cells was markedly altered. These rats also had an impairment of choice accuracy in a discrimination task that required working memory. Within 30 days, however, all EPs had become more normal. Choice accuracy had either returned to criterion levels, or improved substantially above that immediately following the KA injection. Analysis of the EPs indicated that the normal trisynaptic pathway through the hippocampus had been re-established. Neuroanatomical examination of the remaining CA3 pyramidal cells showed a marked increase in cross-sectional area. These data provide an electrophysiological description of the effects of KA on neuronal transmission in the hippocampus, and suggest that the behavioral recovery following these injections was due to sprouting of the remaining CA3 cells which re-established the trisynaptic pathway in the hippocampus.

Animals↗