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Biomedical subjects

K R Joshi

Publications and source records attributed to K R Joshi.

At least 19 recordsLinked to original sources
PubMed2004

Anti-venom-induced myelopathy in a semipoisonous snakebite.

A 40-year-old woman developed myelopathy manifesting as Brown Sequard syndrome after administration of Anti-venom (polyvalent enzyme-refined equine globulin supposed to neutralise 0.6 mg of standard cobra venom, 0.45 mg of standard krait venom, 0.6 mg of standard Russel's viper venom and 0.45 mg of saw scaled viper venom, manufactured by Serum Institute of India, Pune, India). It was concluded to be an immunological inflammation of the spinal cord after ruling out hematomyelia on imaging. The necessity of antivenom in semipoisonous snake bites have been addressed further in the article.

Adult↗
PubMed2000

Cerebral chromoblastomicosis--a rare case report of cerebral abscess and brief review of literature--a case report.

A rare case of Cerebral Chromomycosis caused by chromogenic fungus Cladosporium trichoides in a 35 year old male with classical presentation of cerebral abscess is being presented. The case report lays emphasis on the histological diagnosis of chromogenic fungus in the wall of the abscess cavity, surgically removed from a well delineated circumscribed lesion in the frontal lobe of the cerebrum. The causative fungus could be detected even in unstained paraffin sections. The diagnosis could be made only after surgical removal and histopathological examination. The mycological culture could not be made as the material was received in formaldehyde fixative. The unique features of the case is its recurrence free uneventful survival five years after surgical excision. This is probably the fifth reported case of cerebral chromomycosis from India and first of its type from arid zone of Rajasthan.

Adult↗
PubMed1998

Seroprevalence of toxoplasmosis in Jodhpur, India.

Toxoplasma gondii specific IgG and IgM antibody levels were determined in sera of 135 healthy human volunteers comprising of students (85), staff (50) and 115 patients comprising of 65 adults and 50 children whose blood was taken for some other investigations. None of the subjects had congenital disease or any other sign or symptom suggestive of Toxoplasmosis. None of the women had had obstetric history or gave birth to infants with congenital defects. Toxoplasma gondii specific IgG and IgM antibodies were assayed by ELISA. Sero positivity to one or both classes of antibodies was observed in 17.2%. However, active infection i.e. IgM positive or high (> 210 Eu/ml) level, IgG was observed only in 4.4%. Antibody levels and seropositivity rate increased with age. No statistically significant differences in the levels of antibodies were observed in relation to sex, socioeconomic status, place of living (rural/urban) and dietary habit (vegetarian/non vegetarian). However, relatively higher prevalence of seropositivity was observed in males and villagers.

Adolescent↗
PubMed1997

A simple synthetic liquid medium for development of yeast and mycelial form of pathogenic species of Candida.

Thirty two known strains of Candida species were used for evaluation of glucose, serine, ornithine, methionine, GSOM medium and its comparison with Lee's medium for the production of yeast and mycelial phase at different temperatures and on prolonged incubation. No mycelial form was observed when various Candida species in GSOM and Lee's medium were incubated at 25 degrees C up to 72 hours. Percentage of mycelial forming cells of Candida species were more in GSOM medium than Lee's medium in 48 hours at 37 degrees C. Among various species of Candida, albicans and C. parapsilosis showed maximum mycelium formation. GSOM medium can be used for growing Candida species particularly C. albicans in mycelial phase.

Candida↗
PubMed1996

Immunoglobulin profile in mycetoma.

Serum samples obtained from 25 patients of mycetoma caused by Madurella mycetomi in 18, Streptomyces somaliensis in 5, Streptomyces madurae and streptomyces palletierii from 1 each and also from 25 healthy controls were evaluated for immunoglobulins IgG, IgM and IgA by radial immunodiffusion method using tripartigen plates. All the three classes of immunoglobulins showed increased concentration in cases of mycetoma by M. mycetomi and S. pelletierii. The raised levels of IgG and IgM in cases of mycetoma caused by S. madurae and S. somaliensis where bones were involved, were not statistically significant. IgA was consistently high in all cases of mycetoma irrespective of causative agent and tissue involved. These alterations may possibly reflect relatively poor IgG and IgM response in individuals with extension of mycetoma lesion to bones.

Antibodies, Bacterial↗
PubMed1993

Morphological identification of Candida species on glucose agar, rice extract agar and corn meal agar with and without Tween-80.

A comparative study for the identification of 32 known strains of Candida species on the basis of morphology on glucose agar, rice extract agar and corn meal agar with and without Tween 80 revealed that when Tween 80 is incorporated in the media identification is possible for 96.8% of the species within 48 hours on rice extract agar and for 96.8% of the species within 48 hours on rice extract agar and for 90.6% of the species on glucose agar. The germ tubes and chlamydospores were also produced more on rice extract agar than on 0.1% glucose agar. Rice extract agar with Tween 80 can be used as single medium for morphologic identification of Candida species. The inoculated medium is first incubated at 37 degrees C for 3 hours and examined for germ tube formation and then incubated at 25 degrees C for 24 to 72 hours and examined for appearance of chlamydospores and mycelial morphology.

Agar↗
PubMed1992

A bacteriological study of the environment of pediatric ward and neonatal nursery.

The hospital environment is full of pathogens which may cause nosocomial infections. A bacteriological survey of hospital air, floor, water, milk and fomites was done. The air survey showed large number of bacteria carrying particles in air. A direct relation between floor area per person and bacterial contamination of air was established. The floor survey showed that there is abundance of bacteria on the hospital floors, much more than the accepted fair standards of house keeping. The hospital water had a high coliform and total bacterial count and stored tank water was more dirty. Neonatal nursery milk also had high total bacterial and coliform counts. Regular surveillance of hospital environment may help to reduce the incidence of cross infection.

Cross Infection↗
PubMed1990

Clinical & virological study of dengue fever outbreak in Jalore city, Rajasthan 1985.

An epidemic of acute febrile illness caused by dengue virus occurred in Jalore town, in south-west Rajasthan, in April and May, 1985. Most patients had classical signs and symptoms of dengue fever or had only a mild atypical febrile illness. A few patients had in addition haemorrhagic manifestations/shock or encephalitis. Virological studies (carried out by the National Institute of Virology, Pune) showed that dengue type 3 virus was the main etiological agent. This is the first reported outbreak of dengue in the arid zone in western Rajasthan, that occurred in summer (April-May) in contrast to other parts of India, where such outbreaks are commonly reported after the rains (between August and November).

Adolescent↗
PubMed1985

Mycetoma caused by Aspergillus nidulans in India.

The first case of mycetoma caused by Aspergillus nidulans has been described from India in a young farmer of Jaisalmer situated in the Thar desert of Western Rajasthan, India. The diagnosis was confirmed by histopathological and mycological studies.

Adult↗