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Biomedical subjects

K R Kedia

Publications and source records attributed to K R Kedia.

11 recordsLinked to original sources
PubMed1985

A comparison of the efficacy of an alpha-I-adrenergic blocker in the slow calcium channel blocker in the control of autonomic dysreflexia.

Cystometry, using a portable CO2 cystometer, is a convenient method for detecting autonomic dysreflexia (A.D.) in response to bladder distention. Serial tracings on successive days were found to be consistent. This method was used to compare the effect of the antihypertensive drugs, phenoxybenzamine and nifedipine, in modifying the blood pressure responses of 12 tetraplegic patients. Given as regular medication twice daily, neither drug was effective in preventing A.D. responses to bladder filling, and a significant number of patients developed troublesome hypotension. Nifedipine by mouth was found to be a valuable drug for the treatment of attacks which developed, and capable of preventing an anticipated attack if given shortly before the stimulus. The condition of 'status dysreflexicus' and its appropriate management is described.

Adrenergic alpha-Antagonists↗
PubMed1984

Vasculogenic impotence: diagnosis and objective evaluation using quantitative segmental pulse volume recorder.

Pulse volume recordings were obtained in 60 normal subjects and 74 patients with a history of impotence using a technique that is simple, reliable, inexpensive, reproducible and capable of standardisation. It measures the contributions of all vessels in the penis. The components of the electronic package are described. The pulse volume amplitudes, pulse contours and other measurements in normal subjects are defined. The results give a reliable index of penile blood flow. Pulse volume recordings were also found to correlate with the severity of pelvic angiographic patterns of occlusive disease. Further investigation is necessary to determine the precision with which the method can detect penile blood flow in patients with early vascular disease.

Adult↗
PubMed1983

Penile plethysmography useful in diagnosis of vasculogenic impotence.

Pulse-volume recordings were obtained in 40 normal subjects and 62 patients with history of impotence. In office practice, this study proved to be valuable for estimating penile perfusion. Penile plethysmography is a unique and adaptable screening method for penile blood flow. It measures the contributions of all vessels at the root of the penis. Pulse-volume recordings also were found to correlate with the severity of pelvic angiographic patterns of occlusive disease. Further investigation is necessary to determine the precision with which the method can detect penile blood flow in patients with early vascular compromise.

Blood Volume↗
PubMed1981

Effect of phenoxybenzamine (dibenzyline) on sexual function in man.

Phenoxybenzamine (Dibenzyline) has been extremely effective in treating patients with detrusor dyssynergia. Its minimal side effects include: mouth dryness, nasal congestion, drowsiness and fatigue, nausea and vomiting, palpitations, ejaculatory failure, and retrograde ejaculation. Nineteen men treated with phenoxybenzamine for detrusor dyssynergia reported ejaculatory failure during treatment; normal ejaculation returned after treatment was discontinued. Postmasturbation urine and semen samples were analyzed for sperm and fructose. The results of the study suggest that ejaculatory failure was due to the lack of seminal emission into the posterior urethra, rather than retrograde ejaculation. Some implications of this study are also discussed.

Adrenergic alpha-Antagonists↗
PubMed1981

The management of advanced bladder carcinoma.

Since October 1978, 25 patients with metastatic carcinoma of the bladder have been treated with cis-platinum, doxorubicin hydrochloride and cyclophosphamide. Patient selection for this protocol was relatively strict and included only patients who had measurable parameters. All 3 drugs (60 mg./m.2 cis-platinum, 40 mg./m.2 doxorubicin hydrochloride and 400 mg./m.2 cyclophosphamide) were given as a single dose every 4 weeks. Over-all, 19 of the 23 evaluable patients (82 per cent) responded to therapy. There were 5 complete drug-induced remissions and 14 partial remissions. Generally, the treatment was tolerated well and common toxic effects were myelosuppression, nausea, vomiting and alopecia. One patient died of septicemia as a result of agranulocytosis. These promising results seem to indicate the high degree of effectiveness of this combination chemotherapy against transitional cell carcinoma of the bladder.

Aged↗
PubMed1980

Transureteroureterostomy: an adjunct to cystectomy.

Eight elderly patients with carcinoma of the bladder have been managed over the last three years with cystectomy done along with transureteroureterostomy. The decision for surgery was dictated by intractable bleeding, disabling symptoms, and extensive recurrent lesions of life-threatening degree. All of these patients were a poor risk. All successfully had cystectomy with urinary diversions achieved by transureteroureterostomies in association with a cutaneous ureterostomy. The surgery was done extraperitoneally; the patients were usually ambulated quickly, and the need for long-term nasogastric tubes was obviated. The course and clinical management of these patients are discussed and advantages and disadvantages of this form of urinary diversion presented.

Aged↗
PubMed1975

Sexual function following high retroperitoneal lymphadenectomy.

The mechanism of infertility after high retroperitoneal lymphadenectomy was studied in 36 patients. In 35 patients infertility occurred because of unavoidable seminal vesicular and ductus deferential sympathetic denervation, with consequent aspermia. Potency and orgasm were unchanged in all patients and there was no evidence of retrograde ejaculation. The findings suggest that sympatholytic drugs be studied for possible application as reversible male contraceptives.

Denervation↗