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Biomedical subjects

K R Rao

Publications and source records attributed to K R Rao.

15 recordsLinked to original sources
PubMed1979

Effect of negative pions, relative to 140 kV -- 29 MeV photons and 20 MeV electrons, on proliferation of Ehrlich ascites carcinoma cells.

The effect of negative pions (peak and plateau), photons (140 kV and 29 MeV), and 20 MeV electrons on the proliferative capacity of Ehrlich ascites carcinoma cells was investigated. Proliferative survival curves plotted for the modalities employed are presented. Under the experimental conditions used, the peak pions were more effective than plateau pions by a factor of about 1.4. For 50% survival, 140 kV X-rays had the same effect as peak pions but the latter was more effective (factor 1.2) at 10% survival level. When 140 kV X-rays were taken as the standard, following are the RBE values calculated as 50% survival level: plateau pions --0.73; peak pions --about 1.0; 29 MeV photons --0.73 and 20 MeV electrons --0.6. The results obtained are compared with those reported on other tumor systems and biological test objects.

Animals↗
PubMed1978

Cyclophosphamide induced nail pigmentation.

Cyclophosphamide therapy may occasionally cuase black pigmentation of the nails. We report five cases with this side effect and review the data on eleven cases in the literature. These changes start in the proximal nail beds and progress distally; on withdrawal of cyclophosphamide, clearing of the nail pigmentation proceeds in a similar fashion. The development of the nail pigmentation does not bear any relation to the primary condition for which cyclophosphamide was prescribed. The dose of the drug before the onset of pigmentation ranged from 1.2 to 12.3 g; the duration of treatment ranged from 10 days to 26 weeks. The mechanism of the nail pigmentation is unknown.

Adolescent↗
PubMed1977

The use of frozen, thawed erythrocytes in blood banking: a report of 28 months' experience in a large transfusion service.

A program of component therapy using largely frozen erythrocytes was initiated at Cook County Hospital in July 1973. Use of the three existing washing systems for routine preparation of frozen erythrocytes has shown that there are differences in the levels of free hemoglobin, hematocrit, and residual glycerol in the washed products. Adenosine triphosphate, 2,3-diphosphoglycerate, and extracellular potassium and sodium were found to be within acceptable limits. Some expired units were cultured and were found to be positive for Staphylococcus and Corynebacterium. The source of contamination has not been determined. Frozen blood, when available, has been given to all patients, regardless of age or clinical condition. The incidence of transfusion reactions has decreased from 0.57% prior to the inception of the component therapy program to 0.11% since that time. Two cases of possible posttransfusion hepatitis occurred in patients who had received non-frozen blood, and in three patients who received non-frozen erythrocytes and/or components as well as frozen blood. Although the goal of the program was the use of frozen erythrocytes exclusively, only 64% use was achieved, as sufficient quantities of blood for freezing were not available at all times.

Blood Banks↗
PubMed1977

Rutosides and radiation induced regression of experimental tumours.

The effect of some flavonoids like O-(beta-hydro-xyethyl)-rutoside, alone and in combination with X-rays, was investigated on three transplantable mouse tumours. The growth characteristics of the tumours depending on the sex of the host animal and the application of flavonoids are described. Under the different experimental conditions exployed involving 1500 mice, flavonoids did not alter the radiation effect on the tumours as neither a protective nor a sensitizing effect was observed.

Animals↗