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Biomedical subjects

K R Sedov

Publications and source records attributed to K R Sedov.

At least 37 records · Page 2Linked to original sources

[Variability of anthropometric traits at birth in healthy children and children suffering from acute respiratory diseases in the first year of life].

Variation of 5 anthropometric traits at birth in groups of normal children who had suffered from acute respiratory diseases during their first year of life was studied in Russian migrant and native population inhabiting the Western area of Baikal-Amur Railway. It was shown that affected children from migrant and native population had lower average values of all traits, as compared with normal children. In order to reduce the number of variable, the principal component analysis was applied. Stronger similarity was found between groups of normal children from native and migrant populations than between normal children and affected children from one population. This can be the evidence of the formation of similar adaptive norm for children from both Russian populations.

Acute Disease↗

[Nonspecific inherited risk factors for acute respiratory diseases in children living in the western part of the Baikal-Amur railway].

Variation of 9 polymorphic loci was compared in 2 groups of children from Russian native and migrant population of Western area of Baikal-Amur Railway--those who suffered from acute respiratory diseases during first year of life and their parents, and normal children and their parents. Frequencies of genotypes 1-1 (HP locus). 00 (ABO locus), and pp (F locus) were significantly higher in normal children than in the affected ones. Heterozygosity observed in native parents of the diseased children was lower as compared with other groups. It was possible to distinguish two groups, according to the degree of genic similarity: the first one included healthy children and their parents from migrant and native population, the second one included all affected children and their parents. Significance of association between phenotypes at 3 loci (HP, ABO, P) and predisposition of the children to acute respiratory diseases were evaluated. A conclusion was made that in children of both migrant and native Russian parents similar combinations of anthropological traits and gene markers are the factors of their nonspecific resistance to acute respiratory diseases.

Child↗