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Biomedical subjects

K Rappersberger

Publications and source records attributed to K Rappersberger.

65 records · Page 4Linked to original sources
PubMed1988

[Cholesterol embolization following anticoagulant treatment].

A 65-year-old female patient with pulmonary embolism developed widespread, extremely painful hemorrhagic necroses of the skin and subcutaneous tissue of the lower extremities 5 weeks after initiation of anticoagulation therapy. Due to the clinical and histopathologic findings and the course of the disease, a diagnosis of cholesterol embolization was made. The characteristic features of this clinical entity and differential diagnostic considerations are discussed.

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PubMed1987

Vegetating cicatricial pemphigoid. A new subset of the cicatricial pemphigoid spectrum.

A case with widespread vegetating-pustular skin lesions, oral erosions, ulcerations and scarring, and conjunctival synechiae is reported. Clinically, histopathologically, and by immunofluorescence and electron microscopy this patient combined the features of pemphigoid vegetans, as described by Winkelmann and Su, and the mucocutaneous type of cicatricial pemphigoid. This observation suggests that a third subset of cicatricial pemphigoid can now be added to the two existing ones, the mucocutaneous and Brunsting-Perry types, and the designation vegetating cicatricial pemphigoid is proposed for this heretofore undescribed condition.

Aged↗
PubMed1987

[The glucagonoma syndrome].

We report on our experience with two patients with glucagonoma syndrome and review the recent dermatologic literature. The clinical features are described with special emphasis on necrolytic migratory erythema, the characteristic cutaneous sign of glucagonoma syndrome. Using our histological and ultrastructural findings, we discuss the pathogenesis of necrolytic migratory erythema. Pathognomonic laboratory data and the diagnostic procedures recommended for the evaluation of patients with glucagonoma syndrome are presented. Finally, we discuss the differential diagnosis and describe therapeutic possibilities in the management of this syndrome.

Adenoma, Islet Cell↗
PubMed1987

[Lymphomatoid granulomatosis].

We present two patients with lymphomatoid granulomatosis (LG) which was diagnosed from the histopathology of cutaneous lesions. Combined cytostatic and corticosteroid treatment induced transient, partial remission in one case, but a lethal outcome could not be prevented in either case. Monoclonal-antibody typing of lesional infiltrates indicated that LG is a malignant T-cell lymphoma.

Aged↗
PubMed1986

Morphological changes in peripheral blood cells and skin in amiodarone-treated patients.

Amiodarone, used in the treatment of cardiac arrhythmia, may lead to severe discolouration of sun-exposed skin. The lysosomal storage of a lipid-like material has been shown to be the morphological substrate for this cutaneous hyperpigmentation. Examination of peripheral white blood cells of amiodarone-treated patients disclosed identical lysosomal structures indicating that amiodarone treatment leads to a more generalized lysosomal storage of lipids and of amiodarone and its metabolites.

Amiodarone↗
PubMed1986

Tubuloreticular structures in Kaposi's sarcoma: a comparison of the classical and AIDS-associated forms.

The ultrastructural morphology of both the classical and the AIDS-associated forms of Kaposi's sarcoma was examined electron-microscopically. Tubuloreticular structures were found only in the AIDS-associated form of Kaposi's sarcoma, and not in the classical variant of the tumor. Moreover, the tubuloreticular structures, 20-30 nm in diameter, were present in very high numbers and in two different forms: the loosely intertwined tubuli, which were clearly predominant; and those forming a more compact pattern. These findings suggest that the presence of tubuloreticular structures may well be an ultrastructural marker for diagnosing AIDS and AIDS-associated disorders.

Acquired Immunodeficiency Syndrome↗
PubMed1985

[Pemphigus vegetans (Hallopeau) with eosinophilic spongiosis--successful retinoid therapy].

We present an unusual case of pemphigus vegetans (Hallopeau) with widespread, nonblistering gyrate erythematous lesions on the trunk and extremities in addition to typical vegetating lesions in the inguinocrural area. The histopathology which was characterized by eosinophilic spongiosis, as well as immunofluorescence and immunoelectron-microscopic studies indicated that the gyrate erythema (characterized by eosinophilic spongiosis) seen in our patient represented a manifestation of pemphigus. Treatment with retinoids resulted in the prompt disappearance of the gyrate erythemas, and the eosinophils returned to normal. A short-term, low-dose corticosteroid regimen also led to rapid healing of vegetating lesions.

Aged↗