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Biomedical subjects

K Reddi

Publications and source records attributed to K Reddi.

47 records · Page 3Linked to original sources
PubMed1986

Human esophageal carcinoma cell lines: prostaglandin production, biological properties, and behavior in nude mice.

Prostaglandin production by two continuous human esophageal carcinoma cell lines HCU 18 and HCU 39 derived from poorly and moderately differentiated source tumors, respectively, was investigated. Behavior of both lines in vitro and upon sc inoculation into athymic randombred BALB/c nude mice was also assessed. Approximately half the xenografts induced by HCU 18 cells were invasive, whereas those initiated by HCU 39 cells were all well encapsulated. Although metastases were not detected in mice given injections of HCU 39 cells, metastatic tumors developed in 2 mice inoculated with HCU 18 cells. In addition, HCU 18 cells produced significantly more prostaglandin E (PGE) and prostaglandin F (PGF) than HCU 39 cells. These findings suggest a relationship between PGE and PGF production by human esophageal carcinoma cells and their invasive and metastatic potential in athymic mice.

Animals↗
PubMed1986

Various methods for determining urinary choriogonadotropin evaluated for the early diagnosis of ectopic pregnancy.

We evaluated the accuracy, sensitivity, specificity, and performance characteristics of seven methods for determining urinary choriogonadotropin in the early diagnosis of ectopic pregnancy in 46 patients with gynecological emergencies. The kits examined included immunoenzymometric assays (Tandem Icon hCG, Model Plus, Diapreg-25, Pregnastick, Nimbus) and reverse hemagglutination inhibition assays (NeoPregnosticon 75 Duoclon, Pregtest). We found immunoenzymometric assays to be the most sensitive procedures (lowest detection limits) for qualitatively detecting hCG secreted by ectopic pregnancy. We concluded that the Tandem Icon best meets our criteria and we advocate its use in the emergency room or ward as the first-line investigation of ectopic pregnancy. In addition, the use of Diapreg-25 has many theoretical advantages as an extremely sensitive index of choriogonadotropin status because of its ability to detect very low concentrations of beta subunit.

Chorionic Gonadotropin↗
PubMed1986

Pituitary tumours in African and Indian patients.

Over a five year period 55 patients with pituitary tumours (35 African and 20 Indian patients) were seen at the Endocrine Unit, King Edward VIII Hospital. Of the 33 patients with secretory tumours 20 had GH-secreting tumours (acromegaly), 8 prolactinomas and 5 ACTH-producing tumours (Cushing's disease); in addition 4 of the patients with acromegaly probably had combined GH and prolactin secreting tumours. The group with non-secretory tumours comprised 13 patients with craniopharyngioma, 7 with chromophobe adenomas and 2 patients with parasellar tumours. The majority of patients with non-secretory tumours were of African descent. Hormonal deficiencies present in the patients tested, were as follows: GH deficiency 73.3%; hypocorticolism 66.7%; hypogonadism 35.9% and hypothyroidism 14%. It thus appears that the patients in the present study differ from populations studied elsewhere with respect to the relative frequency of the various secretory tumours and the prevalence of certain hormonal deficiencies.

Acromegaly↗
PubMed1986

Changes in amniotic fluid prostaglandins with oxytocin-induced labor.

Amniotic fluid prostaglandin levels were measured serially in 15 patients who underwent successful induction of labor and compared with those of patients presenting in spontaneous labor. At comparable cervical dilation the induced group demonstrated significantly lower prostaglandin levels. Four of these patients delivered without any increment in prostaglandins while in the remaining patients increases in prostaglandins followed the attainment of efficient uterine contractions by several hours. These data support the hypothesis that oxytocin acts directly on myometrial cells and not primarily by prior generation of prostaglandin synthesis in the membranes.

Amniotic Fluid↗
PubMed1985

Male transmission of the gene for isolated gonadotropin-releasing hormone deficiency.

Three black women, daughters of the same father but three unrelated mothers, presented with isolated gonadotropin deficiency (IGD). Clinically, the patients had no midline defects and intact smell and taste senses. Biochemically, the essential feature was very low unstimulated and stimulated follicle-stimulating hormone and luteinizing hormone levels, even after priming with gonadotropin-releasing hormone over a 5-day period. Growth hormone response to insulin-induced hypoglycemia was somewhat blunted, but prolactin, cortisol, and thyroid-stimulating hormone responses were quite normal. All three patients had the 46,XX karyotype; clinical or biochemical aberrations could not be demonstrated in any of the remaining family members. The disorder was, apparently, transmitted by the deceased father, who manifestly did not have an IGD deficiency nor any of the midline stigmata associated with IGD. The mode of inheritance seems most likely to be autosomal dominant with variable penetrance.

Adolescent↗
PubMed1984

Central venous concentrations of immunoreactive prostaglandins E, F, and 6-keto-prostaglandin F1 in eclampsia.

Concentrations of prostaglandins E, F, and 6-keto-prostaglandin F1 alpha were estimated in central venous blood and amniotic fluid in 21 women with eclampsia and 16 healthy pregnant controls. Central venous blood concentrations of 6-keto-prostaglandin F1 alpha and prostaglandin E were significantly lower in patients than controls before delivery and remained reduced for at least 48 hours after delivery. Low concentrations of prostaglandins E and 6-keto-prostaglandin F1 alpha are probably directly related to the pathogenesis of eclampsia.

6-Ketoprostaglandin F1 alpha↗
PubMed1984

Abnormal concentrations of prostaglandins in amniotic fluid during delayed labour in multigravid patients.

Concentrations of prostaglandins E (PGE), F2 alpha (PGF), 13,14-dihydro-15-keto prostaglandin F2 alpha (PGFM), 6-keto F1 alpha and thromboxane B2 were measured by specific radioimmunoassay in samples of amniotic fluid from 22 multigravid patients during labour. Normal labour in 10 patients was associated with a significant increase of PGE, PGF and PGFM with close correlation to cervical dilatation (P less than 0.05). In the 12 patients with clinically delayed labour, in the absence of cephalopelvic disproportion, there were significantly lower PGF (P less than 0.002) and PGFM (P less than 0.05) concentrations obtained while no differences were observed in the other prostanoids measured. Administration of oxytocin to the latter group to enhance labour did not have any effect on the concentrations of prostaglandins obtained in spite of an improvement in intrauterine pressures and accelerated progress of labour.

6-Ketoprostaglandin F1 alpha↗
PubMed1984

Amniotic fluid prostanoids in preeclampsia.

Amniotic fluid from 19 patients with preeclampsia was compared with samples from normotensive control subjects with respect to the levels of prostaglandin 6-keto prostaglandin F1 alpha, thromboxane B2, and the ratio of 6-keto prostaglandin F1 alpha to thromboxane B2. The study found no significant differences in the levels of these prostanoids or the ratio of 6-keto prostaglandin F1 alpha to thromboxane B2 (study patients, 2.7 +/- 2.1; control patients, 2.8 +/- 1.9) between groups.

6-Ketoprostaglandin F1 alpha↗