Biomedical subjects

K Rehse

Publications and source records attributed to K Rehse.

At least 73 records · Page 4Linked to original sources

PubMed1990

[Antiaggregatory and anticoagulant effects of oligoamines. 12. Alkyl- and arylalkyl- derivatives of putrescine, spermidine and spermine].

Eleven lipophilic derivatives of the title biogenic amines and 28 structurally related triamines and tetramines have been synthesized. Twenty-three of them inhibited the platelet aggregation induced by collagen at an IC50 between 8 mumol/L and 30 mumol/L. Five compounds prolonged the one stage thromboplastin time (Quick) by 7s or more at 100 mumol/L. The antiplatelet and anticoagulant effect do not run parallel. The relationship between the effects observed and the chemical structure of the oligoamines has been elucidated.

Anticoagulants↗

PubMed1990

[Aggregation inhibiting and anticoagulant effects of oligoamines. 13. Improvement in the storage of whole blood and erythrocyte suspensions with oligoamines].

The impairment of the functions of red blood cells or their destruction during storage can be delayed or even inhibited by oligoamines especially RE 1492 (N,N',N''-Tris-(4-phenylbutyl)benzene-1,3,5-trimethanamine). When citrated whole blood (WB) is stored at 4 degrees C for 7 d half of the red blood cells (RBC) have lost their ability to form rouleaux. Addition of 100 mumols/L RE 1492 maintains 50% reaggregability up to day 28th of storage. When citrated WB is stored at 37 degrees C the reaggregability has declined to 40 percent after 10 h. With 100 mumols/L RE 1492 no reduction of this property is observed up to 48 h. These results are correlated with the maintainance of the discocyte form of RBC and a persistent filtrability of RBC suspensions through a 5 microns microporous membrane. With 100 mumols/L RE 1492 only one fifth of the haemolysis of untreated WB occurs. The efflux of potassium ions from RBC into the blood plasma during a 72 h storage is bisected by RE 1492. The binding of oxygen to RBC remains unchanged.

Anticoagulants↗

PubMed1989

[Determination of the protein binding of drugs by continuous ultrafiltration. 9. Comparison of the binding of nonsteroid antirheumatics to human serum albumin and their interaction with phenprocoumon].

Binding to HSA has been determined for diflunisal (alpha = 0.03%), diclofenac (0.09), ibuprofen (0.10), bumadizone (0.11), ketoprofen (0.14), oxyphenbutazone (0.28), indomethacin (0.39), mofebutazone (0.57), tenoxicam (0.59), piroxicam (0.91), salicylic acid (1.00), o-carbamoylphenoxyacetic acid (11.58) and salicylamide (24.91). The free concentration of phenprocoumon was raised by diflunisal up to 35% in a dose dependent manner. Ibuprofen and piroxicam did not show significant effects. It is concluded that diflunisal is bound only slightly to the phenoprocoumon binding site of HSA while ibuprofen has no affinity to this part of the albumin molecule.

4-Hydroxycoumarins↗

PubMed1989

[Antiaggregatory and anticoagulant effects of oligoamines. 10. Tertiary oligoamines and quaternary ammonium salts].

Twelve tertiary oligoamines, two quaternary oligoammonium salts, two oligoamides, one oligosulfonamide, and one trinitrosamine were tested for antiplatelet and anticoagulant effects. Seven amines and one ammonium compound inhibited platelet aggregation at IC50 below 100 mumols/L. The results suggest that the formation of hydrogen bonds to phospholipids strengthens the antiplatelet activity. The sterical limits of the structural variability concerning the antiaggregatory effects are shown.

Amines↗

PubMed1988