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Biomedical subjects

K Ricker

Publications and source records attributed to K Ricker.

At least 91 records · Page 5Linked to original sources
PubMed1977

Myotonia not aggravated by cooling. Force and relaxation of the adductor pollicis in normal subjects and in myotonia as compared to paramyotonia.

The effect of local cooling has been studied in 27 normal subjects, 8 cases of myotonia congenita, 5 of myotonic dystrophy and one of paramyotonia. Using the adductor pollicis we registered the compound muscle action potential, the isometric twitch force and the time to half relaxation, the maximum tetanic force and to time 3/4 relaxation. 1. In normal subjects the twitch force and maximum tetanic force decreased after cooling (Fig. 2). The amplitude of the action potential increased. 2. Myotonia congenita and myotonic dystrophy were not aggravated by cooling. Muscle force was reduced only in the same proportion as in normal subjects (Fig. 2). The myotonic after-contraction was made normal by cooling (Figs. 5 and 6). 3. In paramyotonia initial tonic stiffness with a pronouncedly prolonged twitch relaxation occured directly after cooling (Fig. 1 B). Paradoxical myotonia occured only after exercise and was accompained by increasing paresis (Figs. 3 and 8). The results indicate that exposure to cold has a specific effect on muscle function only in paramyotonia.

Adolescent↗
PubMed1977

Increased voltage of the muscle action potential of normal subjects after local cooling.

The compound muscle action potential (MAP) and the isometric twitch force of the adductor pollicis of 25 normal subjects were registered after local cooling. Intramuscular temperature ranged from 36.6 to 18.0 degrees C. The amplitude of the MAP increased while the twitch force decreased at lower temperatures. The increase of the MAP could be caused by the effect of cooling directly at the muscle cell membrane. The decreased twitch force probably is due to an affect on the contractile apparatus.

Action Potentials↗
PubMed1977

The regional curare test in myasthenia gravis.

30 subjects without disturbance of neuromuscular transmission and 18 patients with myasthenia gravis were used in conducting the regional curare test. The adductor pollicis and the hypothenar muscles were studied with the 3/sec stimulation test. With three different dosages of curare one could find no reliable border between "normal" and "pathological". In the patients with myasthenia no definite relation could be found between the findings with the regional curare test and the clinical picture. The curare concentration reaching the muscle is probably quite variable from case to case as regards diffusion and volume in the tissue. The 3/sec stimulation test with registration from the deltoid muscle, and in certain cases the systemic curare test, appear more suitable than the regional curare test for routine diagnosis as well as indication for thymectomy. But for cases of ocular myasthenia showing no further weakness by the systemic curare test, the regional curare test can be put to use. The advantage lies in the higher concentration of curare which can thereby be brought to the muscle. The precautionary measures should be similar to those taken with the systemic curare test.

Adolescent↗
PubMed1976

Electrophysiological findings in the syndrome of acute ocular muscle palsy with ataxia (Fisher syndrome).

4 patients are described with ophthalmoplegia (Figs. 1 and 2) and ataxia with acute onset. Three of them showed only very slight symptoms of generalized polyneuritis. Measurement of sensory nerve conduction velocity (Fig. 4, Table 2) and determination of vibration sense by an electrical vibrator (Fig. 3) proved to be helpful for diagnosis. The ocular EMG revealed signs of peripheral denervation in 3 cases. Pathological changes of the somatosensory evoked potential (Fig. 5) which has been registered in one case, might give some speculation as to whether or not central nervous pathways are affected.

Adult↗