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Biomedical subjects

K Rifat

Publications and source records attributed to K Rifat.

33 records · Page 2Linked to original sources
PubMed1978

[Visual identification of Doppler sounds in gas embolisms].

The method of choice for the early detection of air metabolism during neurosurgical operations in a sitting position is that of continuous cardiac auscultation using Doppler effect ultrasound apparatus. In the present study, involving 15 patients, an air embolism was produced by the injection of 2 ml of CO2 into the right heart and acoustic changes were recorded on paper using a photographic process. These optical changes, although variable, were invariably present and characteristic of aire emboli and represent an additional element in early diagnosis.

Adult↗
PubMed1976

[Etomidate: cardiovascular effects of a new intravenous anesthetic agent].

The cardiovascular effects of intravenous Etomidate (0.2 mg/kg) were studied in 14 surgical patients with ages varying from 49 to 90. The anaesthetic induction occurs within 10 seconds and the mean duration of anaesthesia is from 6 to 8 minutes. I.V. Etomidate causes a slight lowering of the mean arterial pressure (8.5 per cent), a negligible increase of the heart rate (2.8 per cent) and an insignificant lowering of the mean pulmonary artery pressure (7 per cent). Cardiac output and stroke volume are respectively lowered by 7.6 per cent and 10 per cent. The peripheral vascular resistance is discreetly reduced by 3.8 per cent. From these results, we believe that Etomidate seems to induce sleep with the lightest hemodynamic disturbances in comparison with other agents commonly used. However, some undesirable side effects appeared in some of our patients which can become somewhat annoying, for example myoclonic movements and pain at the point of injection.

Aged↗
PubMed1976

[Effects of Etomidate on ventilation and blood gases].

17 surgical patients, agent 49 to 87, are studied. Their anaesthetic induction was performed by an intravenous injection of Etomidate on a 0,23 mg/kg body weight basiis. Respiratory frequency and minute ventilation were put on continuous recording, PO2, PCO2 and arterial blood pH were measured 1,3 and 5 minutes after injection of the drug. Anaesthetic induction, occuring 10 seconds after injection of the drug, was followed by an increase in respiratory frequency (32 p 100) and a rather modest increase of minute ventilation (9,2 p. 100). Among blood gases measurements, only PaO2 showed a decrease of 6,7 p. 100, when PO2 and pH remained practically unchanged. The small increase in minute ventilation, compared with a relatively important increase in respiratory frequency, suggests some decrease in efficient alveolar ventilation without however affecting blood gases in an important fashion.

Aged↗
PubMed1975

[Clinical investigations of the steroid anaesthetic agent CT-1341 (Althesin) (Cardiovascular and respiratory effects)].

The new steroid anaesthetic CT-1341 (Althesin) has been used as an induction agent in dose of 0.07 ml/kg body weight. Following injection, stage 1 anaesthesia is reached in an average of 30 sec with a clinical duration of between 12 and 20 min with total recovery, supported by a normal pre-anaesthetic EEG tracing, in 40 to 50 min. The respiratory depression following injection in characterized by a short period of apnea followed by an increased respiratory rate and a diminished tidal volume; there is a decrease of the pO2 of about 15%, but the pCO2 and pH values do not show significant variations. Concerning its action on the cardiovascular system, there was found an increase of heart rate (+14%), a decrease of both systolic (-19%) and diastolic pressures (minus decrease of both systolic (-19%) and diastolic pressure (-13.5%), central venous pressure and the peripheral vascular resistance (-14%) with hardly any change in the pulmonary artery pressure.

Adult↗
PubMed1975

[Hemodynamic effect of enflurane in man].

The following hemodynamic parameters: cardiac frequency, peripheral arterial pressure, pulmonary pressure and cardiac output were measured by direct catheterisation, as the total peripheral vascular resistance and the systolic ejection volume were calculated from the registered results. The cardiac frequency and the pulmonary arterial pressure were practically not modified in our patients, though we have observed a statistically significant decrease of systolic (-30p. 100) and diastolic (-27p. 100) arterial pressure. The total peripheral vascular resistance shows a marked diminution (-20p. 100) after giving Ethrane? for ten minutes. If it is possible that one part, surely important, of the cardiac output, is preserved under Ethrane anesthesia by a significant decrease of the total peripheral vascular resistance, a myocardial depression might be questionned, the decrease of cardiac output at 30 minutes being more important than the decrease of the total peripheral vascular resistance.

Anesthesia, General↗
PubMedDate not supplied

[Cardiovascular effects of Rohypnol used as an agent to induce anesthesia].

The study involved 34 surgical patients in whom anaesthesia was induced by the intravenous injection of an average dose of 2.5 mg of flunitrazepam (Rohypnol or Ro-5-4200). The induction of anaesthetic sleep was obtained in 50 to 60 seconds and the duration of the anaesthetic effect 15 to 20 minutes. The patients continued to show hypnosedative effects for several hours postoperatively. The cardiovascular parameters studied - radial BP, ECG and pulmonary arterial pressure - were recorded directly whilst cardiac output was measured by thermodilution using a Swan-Ganz catheter. The decrease in systolic and diastolic pressures in relation to pre-anaesthetic values was 21 p. 100 and 16 p. 100 respectively, whilst pulmonary artery pressure fell by 13 p. 100. Cardiac output fell in a non-significant fashion and the same applied to systolic ejection volume for a given constant heart rate. There was a significant (18 p. 100) decrease in total peripheral resistance but alterations in central venous pressure were negligeable. The decrease in peripheral vascular and pulmonary artery resistances suggest that the product has a peripheral circulatory action and it is possible to correct the alterations seen.

Anesthesia, General↗
PubMedDate not supplied

[Per- and postoperative buprenorphine analgesia: cardiocirculatory and respiratory effects].

In 25 non-premedicated patients, buprénorphine (5 micrograms/kg - 1) has been injected i.v. 30 mn before coelioscopic sterilization under general anaesthesia. Following the i.v. injection there no significant modification of the arterial systolic and diastolic blood pressure was observed but post-operative bradycardia. Tidal volume and minute/ventilation decreased whereas the respiratory rate remained stable. Arterial blood gaz analysis showed slightly hypoxaemia and a significant rise of PaCO2 with post-operative acidosis similar to that in the control group. Good postoperative analgesia was achieved but with profound sedation and a high incidence of nausea and vomiting.

Adult↗