A method for estimating rates of nucleotide substitution using DNA sequence data.
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K Risko
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An improved method for estimating sequence divergence of DNA using restriction endonuclease mappings.
The method proposed by Kaplan and Langley for estimating the extent of sequence divergence between related DNA's using restriction endonuclease maps is modified so that the estimates are easier to compute. In the two-species case, these modifications lead via a maximum likelihood approach to an estimate which is closely related to one recently suggested by Nei and Li (1979) and Gotoh et al. (1979). Simulation studies show that the modified estimates are comparable to those of Kaplan and Langley, providing that there is sufficient homology in the DNA segments of the related species. The M-species case, M greater than or equal to 3, is also discussed.
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