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Biomedical subjects

K Robock

Publications and source records attributed to K Robock.

18 recordsLinked to original sources
PubMed1975

1975 Yant Memorial Lecture New aspects on dust and pneumoconiosis research.

This lecture deals with pneumoconiosis, in particular with fibrotic tissue reactions caused by SiO2 and asbestos dusts in the lungs. The term "fine dusts" is defined in connection with the setting up of MAC-values. The aerodynamical diameter of particle shaped and fibrifom dust is set forth. Results of the fundamental research with SiO2, Coal mine and asbestos dusts in animal and cell experiments are explained.

Animals↗
PubMed1975

The biological effect of asbestos and asbestos cement products.

The importance of the physical characteristics, rather than the chemical composition of fibres, in relation to their alveolar deposition and biological effects is stressed. For alveolar deposition in the aerodynamic properties--depending on the fibres diameter--are decisive, whereas in the interaction between macrophages and fibres, fibre length is the decisive factor for cytotoxicity. Probably fibre length could, inter alia, be responsible for a pathogenic effect around the lung tissue. The results from measurements of the cytotoxicity of the UICC standard asbestos dusts and pure cement dust are presented and discussed.

Asbestos↗
PubMed1975

Results of epidemiologicalm mineralogical and cytotoxicological studies on the pathogenicity of coal-mine custs.

Risks of developing abnormalities on chest X-rays differ widely between collieries in the Ruhr, despite comparable dust exposures. Simple pneumoconiosis hazard indices have been determined for thirteen collieries, taking into consideration variations in miners' individual cumulative dust exposures, their ages at start of dust exposure, the residence time of dust in their lungs, and the mineral content of the dust. Fine dust samples were taken in five collieries at places selected as representative of seams worked during the past 20 years. They were used for mineralogical and physical analyses and for cell and animal studies. Cytotoxicity of dusts with comparable composition increased with geological age and rank of coal seams. This finding is consistent with results from epidemiological studies.

Coal Mining↗
PubMed1975

Investigations into the determination of the cytotoxicity of quartz dust by physical methods.

The methods of thermally stimulated luminescence (t.s.l), thermally stimulated exoelectron emission (t.s.e.e.), electron spin resonance (e.s.r), and infrared spectroscopy (i.r.) have been used to investigate whether the specific cytotoxic activities of SiO2 dust of various origins can be attributed to physical parameters. After interaction of toxic dusts with water an increase in the intensity of the t.s.l. peaks below room temperature has been detected whereas no effect could be observed in the case of inert materials. Dusts of weak cytotoxicity have been characterized by infrared absorption bands at 3610 cm-1 and 3685 cm-1. The results of the present studies emphasize the significance of silanol groups and adsorption properties in relation to the fibrogenic activity of quartz dusts.

Dust↗