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Biomedical subjects

K Rowińska

Publications and source records attributed to K Rowińska.

16 recordsLinked to original sources
PubMed1993

Single-fibre electromyography (SFEMG) at different firing rates in myasthenia with and without thymoma.

The single fibre EMG differences during motor axonal stimulation at different firing rates were studied in myasthenic patients: 15 with, and 15 without thymoma. 10 healthy volunteers were also examined. Conventional repetitive stimulation EMG as well as SFEMG during weak voluntary contraction and on 10 and 20Hz stimulation was performed in every patient. The mean jitter in the control group was 30 microseconds on voluntary contraction and about 22 microseconds at 10 as well as at 20 Hz stimulation. In both groups of myasthenic patients under consideration SFEMG on voluntary contraction detected neuromuscular transmission disturbances of various degree. The results obtained at motor axonal stimulation (10 and 20 Hz) were unhomogeneous. In both groups jitter seemed to be slightly shorter at higher (20 HZ) frequency stimulation, probably due to facilitation but differences were insignificant.

Adult↗
PubMed1985

Do true remissions in myasthenia really exist? An electrophysiological study.

To answer the question whether true remissions in myasthenia gravis occurred, 20 patients were studied with a history of evident, typical myasthenia but in full clinical remission. Two control groups served as a comparison: one of 10 healthy volunteers and the other of 10 patients with generalized, presently active myasthenia. In 17 of the 20 patients in remission single-fibre EMG (SFEMG) abnormalities were found, indicating some subclinical disturbances of neuromuscular transmission (in 3 cases the results were overtly pathological, in 11 cases moderately pathological, and in 3 cases slightly pathological). The abnormalities found in the remission group were much less distinct than those in the group with clinically symptomatic myasthenia. A case illustrates these findings: a man in full remission following thymoma extirpation in whom the SFEMG revealed subclinical disturbances of the neuromuscular transmission. Three weeks later a full clinical relapse occurred. The results obtained suggest that in the majority of patients the remissions are only apparently complete. A pathological jitter in a patient in remission calls for special attention: the patient must be spared any immunological stimuli such as vaccination, injections of sera, infections etc.; no drugs can be given which may increase the neuromuscular block; an immunosuppressive course of treatment should be considered; prognosis should be reconsidered.

Adolescent↗
PubMedDate not supplied

[Facilitation phenomenon in electrophysiological diagnosis of myasthenia gravis].

A group of 10 patients with atypical result of repetitive stimulation was selected out of the patients examined in our EMG Laboratory. The diagnosis of myasthenia was clinically confirmed. In all those 10 patients no essential amplitude decrement was found on stimulation, so the electrophysiological confirmation of the diagnosis was lacking. On repetitive stimulation (3 Hz) all increment of the response was observed and also post-tetanic facilitation was present. In SFEMG moderate neuromuscular transmission disturbances were found in those patients. It suggests that, sometimes, facilitation may reflect disturbed neuromuscular transmission even despite the absence of the typical amplitude decrement.

Action Potentials↗
PubMedDate not supplied

[A trial of cronassial use in late postpoliomyelitis syndrome].

The results are presented of treatment with gangliosides (Cronassial) in 5 patients with late postpoliomyelitis syndrome. Clinical and electrophysiological examination were done before and after three months of treatment. Only subjective improvement was found. A year-long follow-up failed to fluid progression of the signs and symptoms that, formerly, were progressing slowly. It seems that Cronassial administration (in larger doses and for a longer time) is justified in patients with peripheral motor neuron lesion.

Adult↗
PubMedDate not supplied

[The method of axonal stimulation (AS) for jitter evaluation in the diagnosis of neuromuscular transmission disorders].

The results of jitter measurements in 15 patients with myasthenia gravis and 10 control group persons are presented using single fiber emg (SFEMG) method during weak voluntary activation and intramuscular AS. The method of AS is described, advantages of its use in evaluation of neuromuscular transmission disorders, some limitations and technical traps that the investigator encounters are presented. Jitter values obtained by both methods are compared and existing differences are discussed taking into account two variants of jitter origin.

Axons↗
PubMedDate not supplied

[Changes of sensory threshold of nerve fibres in polyneuropathies].

Subjective and objective sensory threshold (Ts, T(ap)) was measured in the sensory fibres of the median and the sural nerves of patients with diabetic neuropathy, Guillain-Barre-Strohl syndrome, hereditary motor and sensory neuropathy (HMSN I and II) as well as in the carpal tunnel syndrome (CNS). A very marked increase of the Ts was found in HMSN I in both nerves investigated. In HMSN II significant increase of Ts were present only in the sural nerve. In CTS significant increase of Ts was found. Measurements of Ts may be useful in the evaluation of the intensity of sensory nerves lesion.

Adolescent↗