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Biomedical subjects

K Runge

Publications and source records attributed to K Runge.

16 recordsLinked to original sources
PubMed1998

[Is Candida septicemia in premature infants a nosocomial infection?].

Yeast colonization of the vagina is found in about 30% of all pregnant women. Premature infants are severely endangered by generalized fungal infections due to their immature immune system. The objective of this study was to elucidate the relationship between vaginal yeast colonization of the mothers and Candida septicemia in their premature babies. In a prospective study, running from 12/1994 to 8/1996, 176 mothers, facing probable premature birth, were investigated, when hospitalized, for vaginal yeast colonization. 150 premature infants (birth weights ranging from 550 to 2390 g) of these mothers were culturally examined for yeasts in specimens from the mouth, ear, stool and urine immediately after birth as well as once weekly in the following weeks. The patients were divided into two groups. In group A, oral prophylaxis with nystatin was practiced only in infants with at least one positive yeast culture. In group B, all patients received nystatin prophylaxis. Candida septicemia developed one or two weeks after birth mainly in infants with birth weights below 1000 g. Primary oral prophylaxis with nystatin lowers considerably the risk of developing Candida infection.

Candidiasis↗
PubMed1990

How does the end begin? Formation and maintenance of telomeres in ciliates and yeast.

Current models of telomere formation and replication involve either telomerase, a novel ribonucleoprotein, or recombination between the ends of DNA molecules. However, present models will have to be modified to explain recent data on telomere formation in yeast. An understanding of the mechanisms of telomere maintenance in yeast may reveal how other organisms with heterogeneous telomeric repeats replicate their chromosomal termini.

Animals↗
PubMedDate not supplied

[Recombinant tissue plasminogen activator in treatment of fulminant meningococcal infection].

This article reports about a young boy with fulminant meningococcal septicemia. Conventional treatment with antibiotics, intensive care and hemostatic drugs hold up vital functions. Because of extensive purpura fulminans with skin necrosis recombinant tissue plasminogen activator (rt-PA) was used. Under this therapy clinical improvement was observed.

Child, Preschool↗
PubMedDate not supplied

Avian pp60c-src is more active when expressed in yeast than in vertebrate fibroblasts.

Avian pp60c-src, a proto-oncogene product, has been expressed in the yeast, Saccharomyces cerevisiae. pp60c-src from yeast is 10- to 15-fold more active than pp60c-src from mammalian fibroblasts. Extensive phosphorylation of pp60c-src occurs at tyrosine 527 in fibroblasts and inhibits pp60c-src kinase activity. In contrast, pp60c-src from yeast has low levels of phosphate at tyrosine 527. This phosphate may be added by an autophosphorylation reaction that is detectable when immunoprecipitates containing pp60c-src from yeast are incubated with ATP in vitro. This reaction is minor when compared with autophosphorylation at the principal site, tyrosine 416. These data suggest that pp60c-src in fibroblasts is normally inhibited by trans-acting factors, that either directly catalyze phosphate transfer to tyrosine 527 or augment autophosphorylation at this site. Such factors would have the potential to regulate pp60c-src kinase activity. The low but detectable ability of pp60c-src to autophosphorylate at an inhibitory site raises the possibility that pp60c-src may also be auto-regulated.

Animals↗