Biomedical subjects
Publications and source records attributed to K Rutsatz.
An unusual case of nonhealing necrotizing gingivostomatitis in a 66-year-old man is described. Microscopic examination of biopsy material showed an infiltrate of Langerhans cells. Merely oral lesions of Langerhans cell granulomatosis--especially in an old person--occur very seldom.
Human papillomavirus (HPV) infections in oral carcinomas and normal oral mucosa were studied by consensus primer screening and typing for HPV types 6/11, 16 and 18 DNA. After polymerase chain reaction (PCR) the DNA species of interest were identified by Southern blot hybridization with digoxigenin-labeled oligonucleotide probes. Frozen tissue and scrapings were equally suitable for HPV testing and yielded high HPV detection rates in carcinomas. By comparison, HPV analysis of paraffin-embedded material was much less efficient. HPV were demonstrated in 61.5% (16/26) of oral squamous cell carcinomas, high risk HPV 16 and 18 being the preferential types. The frequency of HPV detection in non-neoplastic mucosa of tumor patients decreased clearly with increasing distance from the tumor (range 26.9-3.8%) suggesting focal HPV infections. In contrast, normal buccal mucosa of a group of healthy volunteers contained HPV DNA only in 1% (1/97).
The necrotising sialometaplasia is a rare disease of the orofacial system. The minor salivary glands of the palate are the main localisation. It's clinical importance consists in the possibility of confusion with squamous cell carcinoma or the mucoepidermoid tumor. The authors report on 3 cases and discuss the etiology and the diagnostic of this disease.
The effect on the pulp-dentin system by chlorhexidine 0.2% in comparison to the physiological sodium chloride solution was investigated in animal experiments. The methods of tests were based on the requirements of FDI 1980. After 3, 21, 70 and 90 days the teeth were extracted and prepared for histological studies. The evaluation of the histological preparations including measurement on the residual dentin layer was achieved by light microscopy. Differences in the pulp reaction after treatment of the teeth with chlorhexidine or sodium chloride solution could not be observed. The changes of pulp tissue were slight to moderate and depended on the residual dentin layer. The cavity cleaning with chlorhexidine 0.2% did not cause any additional damage in the pulp.
Within 35 years 1008 patients were treated that were taken ill in a malignant tumor of face, jaw and mouth. There was found in five patients a distant metastasis of a carcinoma in lower yaw. One case with metastasis in left mandibular condyle is being described. The diagnosis was found by using conventional X-ray examination, Computertomography and aspiration cytology.
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