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Biomedical subjects

K S Hartman

Publications and source records attributed to K S Hartman.

17 recordsLinked to original sources
PubMed1994

Fibromatosis of the oral and paraoral region.

The fibromatoses represent a group of infiltrating fibrous proliferations that exhibit a clinical behavior and biologic potential intermediate between benign fibrous lesions and fibrosarcoma. The head and neck region is a common site of involvement for these lesions especially in children and young adults. However, the oral structures per se are not often the site of origin. In this study of 31 cases of fibromatosis that involved the oral and paraoral region, patient ages ranged from birth to 51 years with 74% appearing in the first decade. The most common clinical presentation was a painless mass that involved the cheek, tongue, or submandibular region. Erosion of bone was a frequent finding in lesions arising in soft tissue contiguous with the jaws. After surgical excision, lesions recurred in five patients for a recurrence rate of 23.8%. One lesion recurred twice. The average interval from initial treatment to recurrence was 7.6 months. The recurrence rate observed in this series is significantly lower than that generally reported for fibromatosis of the head and neck (50% to 70%). This is most likely due to the exclusion in this investigation of lesions in the supraclavicular region.

Adolescent↗
PubMed1991

Calcifying odontogenic cyst. A review of ninety-two cases with reevaluation of their nature as cysts or neoplasms, the nature of ghost cells, and subclassification.

Ninety-two cases of calcifying odontogenic cyst (COC) were reviewed with special consideration of their nature as cysts or neoplasms, the nature of ghost cells, and classification on the basis of clinicopathologic features. The cases were divided into 79 (85.9%) cysts and 13 (14.1%) neoplasms. The cysts occurred as four variants: (1) nonproliferative COC (35 cases), characterized by a simple unicystic structure; (2) proliferative COC (17 cases), characterized by a cystic structure with multiple daughter cysts, extensive ghost cell formations, and marked tendency for calcification; (3) ameloblastomatous COC (11 cases), characterized by ameloblastoma-like, cyst-lining epithelium with ghost cells and calcifications; and (4) COC associated with odontoma (16 cases), which combined features of COC and odontoma. The neoplasms occurred as three variants: (1) ameloblastoma ex COC (two cases), which showed unifocal and multifocal intraluminal and intramural ameloblastoma proliferating from the COC-lining epithelium; (2) peripheral epithelial odontogenic ghost cell tumor (eight cases), which occurred in the gingiva and resembled peripheral ameloblastoma except for clustered ghost cells in the central portion of epithelial islands and the presence of juxtaepithelial dentinoid; and (3) central epithelial odontogenic ghost cell tumor (three cases). The latter showed ameloblastomatous or adenomatoid odontogenic tumor-like epithelial clusters with ghost cell formation and juxtaepithelial dentinoid. The clinical features of cystic and neoplastic variants were tabulated and described. On the basis of histopathologic features and their immunohistochemical reaction to polyclonal antikeratin antibody, it is suggested that ghost cells might be the result of coagulative necrosis.

Adolescent↗
PubMed1991

Necrotizing sialometaplasia. A clinicopathologic study of sixty-nine cases and review of the literature.

The clinicopathologic findings in 69 cases of necrotizing sialometaplasia (NS) were analyzed and compared with 115 reported cases of NS in the English-language literature. Data comparing age, sex, race, location, clinical presentation, and possible predisposing factors are summarized. Analysis of the data indicates that NS can occur in a variety of clinical settings and may exhibit a spectrum of histologic features. Recognition of NS, regardless of its clinical or microscopic presentation, is essential to avoid inappropriate or unnecessary treatment for this benign reactive process.

Adolescent↗
PubMed1988

A prospective study comparing incisional labial to incisional parotid biopsies in the detection and confirmation of sarcoidosis, Sjögren's disease, sialosis and lymphoma.

Simultaneous incisional biopsies of labial minor salivary glands and the superficial lobe of the parotid were accomplished in patients suspicious for sarcoidosis, Sjögren's disease, sialosis and lymphomatous changes in Sjögren's disease. Labial minor salivary gland biopsies identified sarcoidosis in 11 of 31 (36%) patients, compared to 29 of 31 (93%) patients using the parotid biopsy (p = 0.005). Similarly, the labial minor salivary gland biopsy confirmed 21 of 36 (58%) patients to have Sjögren's disease, compared to 36 of 36 (100%) (p = 0.005) patients confirmed using the parotid biopsy. Five patients with normal labial salivary gland biopsies were shown to have idiopathic hypertrophic sialosis with enlarged parotids identified by the parotid biopsy. Five additional patients were diagnosed with lymphoma occurring within the parotid glands of patients with Sjögren's disease, via the parotid biopsies, that were not identifiable with the labial minor salivary gland biopsy. The parotid biopsy consistently identified each disease entity in an earlier stage, and with more evident histopathology. Neither technique showed appreciable morbidity. Three of 77 patients showed a sensory loss related to labial salivary gland biopsy. No sensory or motor nerve loss was associated with the parotid biopsy.

Biopsy↗
PubMed1987

Ameloblastic carcinoma: a clinicopathologic study and assessment of eight cases.

The term ameloblastic carcinoma is differentiated from the term malignant ameloblastoma and is defined as an ameloblastoma in which there is histologic evidence of malignancy in the primary tumor or the recurrent tumor (or metastasis), regardless of whether it has metastasized. Eight cases of ameloblastic carcinoma from the Armed Forces Institute of Pathology (AFIP) are reported. The mean age of patients was 30.1 years, with no sex predilection noted. Seven cases involved the mandible and one involved the maxilla, with the posterior regions favored. The most common sign was swelling, although pain, rapid growth, trismus, and dysphonia also occurred. Lesions characteristically were evident as ill-defined destructive radiolucencies, with occasional radiopacities noted. Histologic features generally resembled those of conventional ameloblastoma but with cytologic features of epithelial malignant disease. The clinical course was uniformly aggressive with extensive local destruction and spread, frequent recurrences, and one case of neck node metastasis. The nomenclature and classification of odontogenic carcinomas are discussed, as well as entities that should be included in the differential diagnosis. Further reporting of ameloblastic carcinoma is encouraged.

Adolescent↗
PubMed1984

Plasma-cell gingivitis. Report of a case.

A well-documented case of plasma-cell gingivitis is presented. When viewed in a total perspective, the clinical examination, history of usage of a popular mint , laboratory data and histologic examination provide support for this diagnosis. This patient did not exhibit any evidence of glossitis or cheilitis as is often reported in the literature; however, a positive history to psoriasis was noted. The occurrence of plasma-cell gingivitis in a patient with documented psoriasis provides some interesting speculation regarding the etiologic picture of this condition.

Adult↗
PubMed1980

Histiocytosis X: a review of 114 cases with oral involvement.

A review of 1,120 cases of histiocytosis X yielded 114 cases with oral involvement. Seventy-eight percent of the oral lesions in this series were categorized as monostotic or polyostotic eosinophilic granuloma. The great majority of cases occurred in males, with 40 percent of the lesions having developed before the patient had reached the age of 10 years. The mandible was involved in 73 percent of the cases, and the posterior jaw region was the predominant site. Extraoral involvement occurred in 70 percent, with the most common sites being the skull and lower extremity. The preferred treatment for oral lesions was surgical curettage, and the prognosis was generally very favorable, as evidenced by the over-all recurrence rate of 16 percent.

Adolescent↗
PubMed1978

Central granular-cell tumor of the jaws (the so-call granular-cell ameloblastic fibroma).

Four cases of central granular-cell tumor of the jaws were evaluated to determine the clinical parameters of the lesion, and one of these cases was examined with the electron microscope to investigate the nature of the granular cells. The average age of the patients at the time of treatment was 55 years; all four patients were women. Three of the lesions originated in the mandible, and one in the maxilla. Follow-up studies revealed no recurrences. Electron microscopic examination of one case revealed that the granular cells contained many lysosome-like particles and that these cells are identical to those found in the granular-cell myoblastoma.

Ameloblastoma↗
PubMed1975

Thorotrast-induced extraskeletal osteosarcoma of the cervical region. Report of a case.

This is the seventh reported case of soft tissue sarcoma attributed to thorotrast extravasated during the course of an injection for arteriography. An extraskeletal osteosarcoma occurring the cervical region of a 51-year-old man 30 years after a cerebral arteriogram is presented. The other reported cases include a fibrosarcoma, two neurofibrosarcomas, two spindle cell sarcomas, and an extraskeletal chondrosarcoma. The latency period has varied from 5 to 30 years. The thorotrast granules are readily identified in macrophages near or adjacent to the tumor, and the demonstration of alpha tracks on autoradiographs is diagnostic.

Humans↗