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Biomedical subjects

K S Martin

Publications and source records attributed to K S Martin.

14 recordsLinked to original sources
PubMed1994

Electrostatic forces contribute to interactions between trp repressor dimers.

The trp repressor of Escherichia coli (TR), although generally considered to be dimeric, has been shown by fluorescence anisotropy of extrinsically labeled protein to undergo oligomerization in solution at protein concentrations in the micromolar range (Fernando, T., and C. A. Royer 1992. Biochemistry. 31:3429-3441). Providing evidence that oligomerization is an intrinsic property of TR, the present studies using chemical cross-linking, analytical ultracentrifugation, and molecular sieve chromatography demonstrate that unmodified TR dimers form higher order aggregates. Tetramers and higher order species were observed in chemical cross-linking experiments at concentrations between 1 and 40 microM. Results from analytical ultracentrifugation and gel filtration chromatography were consistent with average molecular weight values between tetramer and dimer, although no plateaus in the association were evident over the concentration ranges studied, indicating that higher order species are populated. Analytical ultracentrifugation data in presence of corepressor imply that corepressor binding destabilizes the higher order aggregates, an observation that is consistent with the earlier fluorescence work. Through the investigation of the salt and pH dependence of oligomerization, the present studies have revealed an electrostatic component to the interactions between TR dimers.

Bacterial Proteins↗
PubMed1994

Informatics issues for nursing's future.

Automated clinical databases are crucial to the future of nursing but presently are not meeting the needs of clinicians, administrators, educators, or researchers. This article examines theoretical, empirical, and practical issues relating to the development of automated nursing clinical databases that will foster safe, effective practice and further nursing's knowledgebase. A series of key questions are identified relevant to each issue. These issues must be resolved if nurses are to take full advantage of the possibilities inherent in the evolving information technology.

Costs and Cost Analysis↗
PubMed1993

Home health clients: characteristics, outcomes of care, and nursing interventions.

OBJECTIVES: The purpose of the study was to provide descriptive data about the characteristics of home health clients, the services that nurses provide, and the outcomes of those services. Such data have been sparse. METHODS: This study examined 2403 home health clients served by four agencies in Nebraska, New Jersey, and Wisconsin. Demographic, health history, and clinical data were analyzed. The Omaha System was used as the model for describing and measuring data specific to clients' health-related problems, nursing interventions, and outcomes of care. RESULTS: The median age of home health clients was 68.6 years. Nurses conducted 70% of all home visits, identified 9107 client problems, and provided over 96,000 interventions. Between admission and dismissal, clients improved by at least 0.52 point on three 5-point problem-specific outcome subscales (Knowledge, Behavior, and Status). CONCLUSIONS: These data show important characteristics of home health clients in a large national sample. They also support the usefulness of the Omaha System in describing and quantifying nursing practice in the community health setting. The magnitude of positive client change between admission and dismissal suggests that community health services do make a difference.

Adolescent↗
PubMed1990

Indoor woodsmoke pollution causing lower respiratory disease in children.

Suggested aetiological factors were evaluated in 244 consecutive children presenting with lower respiratory disease at Marondera Hospital, Zimbabwe. Data obtained from these children were compared with information obtained from 500 children seen at the local well baby clinic. There were no differences in the prevalence of malnutrition, breast feeding, overcrowding, poor housing conditions and poverty in these two groups of children. A significant association was identified between lower respiratory disease and exposure to atmospheric woodsmoke pollution in young children. Air sampling within the kitchens of 40 children revealed levels of atmospheric pollution far in excess of the WHO recommended exposure limit. Elevated carboxyhaemoglobin concentrations confirmed childhood smoke inhalation. We suggest that in many Third World communities a chemical pneumonitis resulting from the inhalation of noxious constituents of woodsmoke predisposes to lower respiratory disease in children.

Air Pollutants↗
PubMedDate not supplied

Application of the nursing process to a continuing education course.

The nursing process is a fundamental component of curricula in schools of nursing. The nursing process also is adaptable to continuing education offerings provided by a nursing education and research department of an urban, community teaching hospital. This article describes how nurse educators used the nursing process as the basis for development, implementation, and evaluation of an advanced medical-surgical continuing education program.

Curriculum↗