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Biomedical subjects

K S Ong

Publications and source records attributed to K S Ong.

8 recordsLinked to original sources
PubMed1992

Punctal dyeing: an adjunct to intraoperative lacrimal punctal identification.

During lid operations, identifying the lacrimal punctum is sometimes difficult. The difficulty may be increased following local anesthetic infiltration into the medial canthus and manipulation of the lid tissues. Punctal dyeing with a skin marking pen is a simple technique that improves visualization of the lacrimal punctum during surgery in this region. Preceded by punctal dilatation, it lasts for the duration of standard lid or lacrimal procedures.

Coloring Agents↗
PubMed1983

Increased 'T lymphocyte' bearing Fc receptors for IgG in pregnancy.

T cell subpopulations as defined by E rosette formation and Fc receptors for immunoglobulins were determined, using ox red blood cells coated with the IgG or IgM fraction of rabbit anti-ox red blood cells antibody to form rosettes with the peripheral blood lymphocytes of 18 pregnant females and 12 healthy nonpregnant females. It was shown that the TG cell population in the pregnant females is significantly increased as compared to those in the nonpregnant controls (mean +/- SEM % TG cells: 18 +/- 1.2 vs. 9.6 +/- 0.7; p less than 0.001). By using peripheral blood from normal nonpregnant subjects it was also shown that TG cells suppressed one-way mixed lymphocyte reactions (mean +/- SEM suppression: 23 +/- 7.2; p less than 0.01). These findings suggest that the TG cell population may exert a suppressor function on the immune response to alloantigens and act in concert with other humoral factors to protect the fetus from rejection.

Adult↗
PubMed1982

The effect of corticosteroid-binding globulin on the in vitro incorporation of thymidine into human lymphocytes.

The purpose of these studies was to examine the inhibitory effect of human corticosteroid-binding globulin (CBG) on the mitogenic effect of phytohemagglutinin on cultured human lymphocytes. We found that CBG could inhibit the incorporation of [14C] thymidine into lymphocytes, but the observed inhibition could be accounted for by the cortisol which was bound to the purified CBG, CBG stripped of cortisol or bound to 11-deoxycortisol was inactive in this assay.

Cells, Cultured↗
PubMed1981

Modulation of Fc receptors of thymus-derived lymphocytes by antigen E in ragweed-sensitive and ragweed non-sensitive subjects.

In ragweed-sensitive and ragweed non-sensitive subjects the proportions of T lymphocytes bearing receptors for the Fc portion of IgG (T gamma) and IgM (T mu) were examined as obtained from the blood, and after treatment in vitro with ragweed antigen E or concanavalin-A. The proportion of T gamma and T mu cells, from the peripheral blood of ragweed-sensitive and ragweed non-sensitive persons, untreated in vitro, were not statistically different. However, when T cells from ragweed-sensitive subjects were exposed to ragweed antigen E, the T mu subpopulation was significantly increased (P less than 0.001) without change in the T gamma population. The reverse change occurred when cells of ragweed non-sensitive subjects were treated with antigen E; there was an increase in the T gamma subpopulation (P = 0.01) but no change in number of the T mu cells. Cells from both the sensitive and non-sensitive groups showed increase in number of T gamma and reduced numbers of T mu cells when incubated with concanavalin A. Since T gamma and T mu cells appear to have a regulatory function on B lymphocyte differentiation and antibody production, the pattern of responses of T gamma and T mu subpopulations in vitro to antigen E in ragweed-sensitive and ragweed non-sensitive subjects may reflect a difference in the cellular control of the immune response to ragweed antigen E.

Adult↗
PubMed1978

Enhancement by oleandomycin of the inhibitory effect of methylprednisolone on phytohemagglutinin-stimulated lymphocytes.

Triacetyloleandomycin (TAO) and its parent compound oleandomycin have a "steroid-sparing" effect in asthmatic patients. This study was designed to determine whether oleandomycin would enhance the inhibitory action of glucocorticosteroids in suppressing the blast transformation of phytohemagglutinin-stimulated human lymphocytes. Although oleandomycin could not be shown to inhibit the phytohemagglutinin stimulation of lymphocytes, there was a significant potentiation of steroid suppression at each concentration of methylprednisolone examined. This augmentation of glucocorticosteroid suppression of lymphocyte proliferation in vitro appears to support the clinically observed "steroid-sparing" effect of TAO and therefore its usefulness may not be limited to asthma and bronchitis.

Adult↗