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Biomedical subjects

K S Puder

Publications and source records attributed to K S Puder.

4 recordsLinked to original sources

Illicit methamphetamine: analysis, synthesis, and availability.

Methamphetamine has been marketed illicitly since the 1960s. Much of the street material was illicitly synthesized. Although methamphetamine quality was variable in the past decade, it has emerged since 1978 as the only street stimulant which is likely to contain what it purports to contain. Although there is a small volume of legitimate methamphetamine still made by the pharmaceutical industry, most material analyzed by street-drug laboratories appears to have been illegitimately synthesized and not diverted. For a decade, relatively little methamphetamine was submitted to street-drug analytical labs. In recent years, although the absolute volume of methamphetamine submissions changed little, this drug made up the bulk of alleged stimulant samples submitted to such facilities because of the paucity of amphetamine submissions. Methamphetamine synthesis and use appears to constitute a small but continuing portion of the illicit drug market.

Humans

Persuading by citation: an analysis of the references of fifty-three published reports of phenylpropanolamine's clinical toxicity.

References cited in scientific articles may be used as data to characterize a body of reports. We examined the references and citations in 53 articles reporting adverse reactions to phenylpropanolamine. We classified the type of reference (case report, human or nonhuman experimental, editorial, or review) and read frequently cited articles to compare their content to their citational use. We searched the references for articles that we thought pertinent including the prospective clinical trial literature and studies comparing phenylpropanolamine with amphetamine. We learned that writers of these reports relied on other case reports and generally ignored experimental literature. These authors also often cited articles so that the original intent was not reflected. Publications presenting an alternative view were largely ignored. This analysis produces some evidence of bias against phenylpropanolamine and that the phenylpropanolamine adverse reaction literature may reflect chiefly social and clinical opinion.

Humans