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Biomedical subjects

K S Rana

Publications and source records attributed to K S Rana.

9 recordsLinked to original sources
PubMed2006

Ischemic stroke following mild head injury is it the cause.

Recognition of childhood stroke is difficult. Newer diagnostic modalities like magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) have made this task much easier. Head trauma usually causes hemorrhage. We are presenting seven cases of mild head injury presenting as ischamic stroke. Neuroimaging suggested infarct involving left basal ganglia and internal capsule in five and bilateral involvement in two cases. MRA done in three was normal.

Brain Infarction↗
PubMed2003

Effect of cybil on reproductive success of wild Drosophila melanogaster.

Cybil (a synthetic pyrethroid) was used to assess its impact on the reproductive success in F1 and F2 generations of wild Drosophila melanogaster. The LC50 has been estimated as 0.0267 microl/100 ml food. Reproductive success has been found to be affected in addition to fecundity and pupation following toxicity of cybil.

Animals↗
PubMed2001

Comparative utility of technetium-99m hexamethylpropylenamine oxime single photon emission computed tomography (SPECT) with anatomic neuroimaging and electroencephalography (EEG) in childhood intractable epilepsy.

Intractable epilepsies pose a therapeutic challenge. Precise localization of the epileptic focus is imperative before planning surgical intervention. Functional imaging is an important component of presurgical work-up. Positron emission tomography is unavailable in developing countries; hence, the need to evaluate the available imaging modality, single photon emission computed tomography (SPECT), was felt. We investigated 61 children with intractable epilepsy, identified by predefined criteria, by performing electroencephalography (EEG), magnetic resonance imaging (MRI), computed tomography (CT), and ictal and interictal SPECT. The localizing value of ictal and interictal SPECT imaging for epileptic foci was correlated with clinical, electrophysiologic, and anatomic neuroimaging data. An ictal SPECT was obtained in 9, and interictal SPECT was performed in all (61). Ictal SPECT was localizing in 8 of 9 (88.8%). Interictal SPECT was localizing in a significantly higher proportion of patients (47.54%) than either the scalp EEG (16.39%) (P = .0003) or CT scan (21.56%) (P = .0046). Our data demonstrated that interictal and ictal SPECT identified more focal changes in children with intractable epilepsy than interictal EEG, CT, and probably MRI. The definitive proof of the SPECT-based findings being epileptogenic foci awaits correlation with intraoperative monitoring and postoperative follow-up.

Adolescent↗
PubMed2000

Rational use of EEG in childhood epilepsy.

Electroencephalogram (EEG) helps in diagnosing seizures and various childhood epileptic syndromes that have significant treatment implications. It represents the electric activity of the brain. Activating procedures can further increase the diagnostic yield. Besides diagnosing, it has a role in discontinuation of treatment and drug monitoring. EEG has its own limitations--it can be normal in an epileptic child and abnormal in a normal one. Electrical activity of the brain varies with age and physiological states like sleep. In neonates the background activity is much more important than epileptiform discharges unless these are repetitive and focal. Pseudo-epileptiform patterns like fourteen and six Hz activity can be confusing. Common typical epileptiform patterns seen in childhood are hypsarrhythmia in infantile spasm, burst suppression in early infantile epileptic encephalopathy, generalised 3 Hz spike wave discharges in absence seizures and periodic complexes in SSPE. EEG patterns like low voltage, electro-cerebral inactivity, multifocal spikes and excessive slow background are associated with poor outcome in neonates. Newer approaches have increased the yield and made localisation more precise. Epilepsy is a clinical diagnosis but EEG has significant role in substantiating the clinical suspicion, classification and management.

Child↗
PubMed1991

Iron overload: detection using a micromethod for iron-binding capacity.

Depending upon the transferrin saturation value, 214 serum samples were divided into three groups--iron overloaded (46 cases), iron deficient (61 cases) and normal (107 cases)--and tested with a micromethod based upon detection of unsaturated iron binding capacity. All the samples with iron overload could be distinguished from the other two groups, the results of the normal and iron deficient groups showing wide scatter and overlap. The high prevalence of iron deficiency anaemia and thalassaemia (iron overload) syndromes in India and other developing countries emphasises the need to differentiate these disorders at the earliest opportunity. The micromethod can be of immense help as it is a simple, rapid and inexpensive.

Anemia, Hypochromic↗
PubMed1986

Plasma transcobalamins in haematological disorders.

Plasma UBBC-B12 and transcobalamins were measured in 112 patients suffering from different haematological disorders. The data showed different patterns of changes in plasma transcobalamin profile in different haematological disorders. Plasma UBBC-B12 and transcobalamins were significantly higher than normal in untreated chronic myeloid leukaemia, acute promyelocytic leukaemia, nutritional megaloblastic anaemia and in refractory anaemias with hypercellular marrow. Normal levels of these proteins were noted in chronic lymphatic leukaemias, in primary and secondary hypereosinophilic states and in multiple myeloma. Subnormal levels of these proteins were observed in hypoplastic anaemia and acute lymphoblastic leukaemia. Chronic myeloid leukaemia patients during blast crisis and acute myeloid leukaemia patients except those suffering from acute promyelocytic leukaemia showed varying pattern of plasma transcobalamins depending on type of blast crisis or FAB subtype of AML. The significance of these changes in plasma transcobalamins have been discussed along with the experience of other workers in this field.

Anemia↗