Biomedical subjects
Publications and source records attributed to K S Saternus.
In comparison to the pattern of lesions of the soft tissue of the neck and the CVC in case of suicidal hanging 17 postmortal fracture-dislocations of the neck are investigated. It could be demonstrated that on principle in case of hanging the dens-fracture can occur. With respect to the hangman's fracture (Wood-Jones) a differentiation into 3 types is proposed.
In 107 cases of suicidal hanging the CVC was investigated systematically. A frequency of lesions at a rate of 65% was found. There were only soft-tissue-lesions with the maximum in C 5/6. The 2nd maximum was the occipito-atlanto-axis-region (C 0/2). This distribution depends on traction. Particularly in the dorsal part the loss of lordosis results from traction. The lesion of C 0/2 is caused by tension due to the weight of the head or by hyperextension due to submental position of the node. 20% of cases showed additional lesions in various locations, which are thought to be results of terminal convulsions.
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The phenotypes of 56 families with 126 children from the Hamburg area as well as gene frequencies and segregation of the genetic markers GPT, AP, ADA, AK, PGM1, PGM3, 6-PGD, CHE, C3, Gc, Tf, Hp and Cp were studied. In regard to linkage, the informative families were correlated to the results of HL-A and GPT typing. The linkage was tested according to the sequential test by MORTON (1955). See article. For other gene loci, linkage to the HL-A or GPT system could not be proved. But the positive lod scores of HL-A/GPT, HL-A/AP and GPT/6-PGD may give indication for linkage.
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BACKGROUND: Every subsequent pregnancy after the loss of a child due to Sudden Infant Death (SID) causes highly anxious parents. The aim of this investigation was to point out which feelings and experiences have to be considered as influencing factors for a following pregnancy--besides being afraid of a repeated loss. The overlapping fixing of our aim was to develop some proposals and recommendations for a capable accompanying during a subsequent pregnancy. MATERIALS: The base of the evaluation were 789 consultations during long-term cares of 115 families affected by Sudden Infant Death (SID). When their children died because of SID 9 of all the mothers were pregnant again. In the families which were cared for half-a-year or longer (n = 80), 47 (58.7%) subsequent pregnancies became known. All gravidities occurred within one year after SID except two cases. RESULTS: We found a strong exigency for information, structure and protection during the whole pregnancy. This fact can be deducted from a high potential of anxiety and fear within the parents. Furthermore, our investigation revealed considerable doubts of the mothers about their parental competence and altered, but still intensive affects of grief yet confidence and great joy as well. Besides, we also observed problematic social experiences, as e.g. hushing up of the dead child or a lacking acceptance of grief by the social environment. CONCLUSIONS: A supporting and reliefing accompanying during a subsequent pregnancy comprises a continuous enlightenment of parents by being honest and open even in giving unpleasant and burdensome informations. It is recommended to show understanding for the exceeding anxieties of the parents, to offer them more possibilities of examinations and conversations as usually appropriate and to talk to them about their dead child and grief. Often the arrangement of contact to a parent-self-help association is the essential offer of support.
The investigation was carried out on 11 sudden infant death (SIDS) cases which were compared with age- and sex-matched controls. Six brain nuclei were selected for evaluation. Using immunohistochemical methods, macrophages were selectively demonstrated by detection of lysozyme; reactive astrocytes, by detection of intracytoplasmic albumin (marker of prior impairment of blood-brain barrier function) or GFAP. No lysozyme-positive cells were demonstrable in the brain stem of any of the examined cases. Although a greater number of reactive, GFAP-expressing astrocytes were found in the SIDS cases, 3 of the 11 SIDS cases (compared to 5 controls) had no reactive astrocytes in any of examined brain nuclei. Reactive astrocytes, however, were identified in more than half the controls. Sections treated with anti-albumin serum were evaluated quantitatively. Total number of non-neuronal cells, relative proportion of astrocytes, and proportion of albumin-positive astrocytes were determined. Paired brain nuclei were counted on both sides of the brain stem. The number of non-neuronal cells, astrocytes, and albumin-positive astrocytes in the SIDS cases did not differ significantly from those in the controls. No statistically relevant difference was established between the right and left parts of the brain stem. The findings were discussed in light of the literature.
Lethal cocaine intoxications in the Federal republic of Germany are still rather unusual. The present article describes chemical findings in a suicide case after oral/nasal intake. Our experience as well as the results of literature leads to the conclusion that if a cocaine intoxication is suspected, examinations are required which should include parts of the brain, the kidneys and the spleen. The application of RIA or rather the EMIT-Procedure only are not sufficient to clear up an intoxication.
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