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Biomedical subjects

K S Shubair

Publications and source records attributed to K S Shubair.

5 recordsLinked to original sources

Acute leukemia in pregnancy: report of five cases treated with a combination which included a low dose of adriamycin.

Five cases of acute leukemia which developed in the course of pregnancy are reported. All five cases received combination therapy which included adriamycin. Two cases were treated during the first half of pregnancy. One of them aborted 2 weeks after commencing therapy but had severe homeostatic failure. The second had a successful pregnancy and delivered a normal infant. Three cases were treated during the second half of pregnancy. All had normal pregnancies and delivered normal infants. The babies have been followed up for periods ranging from 1 month to 3 yr and have shown normal growth and development.

Acute Disease↗

Bronchospasm caused by intravenous hydrocortisone sodium succinate (Solu-Cortef) in aspirin-sensitive asthmatics.

Eleven patients with intrinsic asthma and aspirin sensitivity were challenged with intravenous hydrocortisone sodium succinate (Solu-Cortef; the Upjohn Co., Kalamazoo, Mich.). Three patients showed definite evidence of bronchospasm, which was easily reversed by subcutaneous administration of epinephrine. Evidence is presented which suggests that this reaction was not caused by other constituents of the preparation but rather was caused by Solu-Cortef alone. No atopy was demonstrated in the group as a whole, and the reaction observed was probably nonallergic in nature. We suggest the replacement of intravenous hydrocortisone sodium succinate with dexamethasone in the treatment of such a population.

Adult↗