Biomedical subjects
Publications and source records attributed to K S Ternovoĭ.
Use of new method--laser correlative spectroscopy--was shown bq the authors to be suitable for diagnosis and prognostication of pathological process in orthopedic and traumatological clinics. The method was demonstrated to be highly informative and objective.
Thymic serum activity (TSA) has been studied in 52 healthy subjects, 48 rheumatoid arthritis patients and 17 sufferers with systemic lupus erythematosus aged from 18 to 70. TSA was compared in patients under and over 40 years. In those under 40 TSA appeared significantly inhibited, while in older subjects it did not differ from age-matched control. No correlations were reported between TSA levels and clinical characteristics. Changes in TSA levels may be related both to low content of thymic hormones and formation of inactive complexes from thymic mediators with inhibitors.
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UNLABELLED: The authors studied the levels of large- and medium molecular circulating immune complexes (CIC) and immunoglobulins of main classes (Ig) in 17 patients with systemic lupus erythematosus (SLE) and 47 patients with rheumatoid arthritis (RA). RESULTS: low molecular CIC increased in 35.2% of patients with SLE and in 42.5% with RA; patients with SLE showed a significant reduction of IgA in 80.4%. The IgA/IgM ratio was significantly reduced in SLE due to the above finding. The IgA level remained unchanged in RA.
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The article discusses the authors' experience in treating pyonecrotic and poorly granulating wounds of the upper and lower extremities in 158 patients; proteolytic enzymes, application of carbohydrate sorbents, and helium-neon laser radiation were used in 66 cases. With such method of treatment, the wounds healed without cutaneoplasty in 75% of cases. In 25% of cases free cutaneoplasty was performed after preparation of the wound surface. The terms of wound healing reduced 1.5-2 times as compared to that in the traditional methods of treatment.
The authors have analysed data from literature and their own results concerning multiparameter examination of the patients with rheumatoid arthritis. An effort has been made to establish a correlative relationship between changes in the following immunologic values: the level of rheumatoid factor, circulating immune complexes, antibodies to streptolysin-0 and immunoglobulin G; the number of T-lymphocytes and the quantity of natural cells of the killers and the hormone regulatory activity of thymus. Positive interdependence between the presence of rheumatoid factor and that of antibodies to streptolysin-0 as well as an increase in the content of circulating hormone complexes has been determined. In view of absence of one value which is strictly specific and compulsory for rheumatoid arthritis, it is only complex investigation that allows to describe the trends in changes of the immunologic state of the patient with rheumatoid arthritis.
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